Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase

Mary Bakhanashvili; Elena Novitsky; Ethan Rubinstein; Itzchak Levy; Galia Rahav

doi:10.1128/AAC.49.4.1576-1579.2005

Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase

Mary Bakhanashvili
, Elena Novitsky
, Ethan Rubinstein
, Itzchak Levy
, Galia Rahav

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.

Original language	English
Pages (from-to)	1576-1579
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
Issue number	4
DOIs	https://doi.org/10.1128/AAC.49.4.1576-1579.2005
State	Published - Apr 2005
Externally published	Yes

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10.1128/AAC.49.4.1576-1579.2005

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title = "Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase",

abstract = "We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.",

author = "Mary Bakhanashvili and Elena Novitsky and Ethan Rubinstein and Itzchak Levy and Galia Rahav",

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Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase. / Bakhanashvili, Mary; Novitsky, Elena; Rubinstein, Ethan et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 4, 04.2005, p. 1576-1579.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase

AU - Bakhanashvili, Mary

AU - Novitsky, Elena

AU - Rubinstein, Ethan

AU - Levy, Itzchak

AU - Rahav, Galia

PY - 2005/4

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AB - We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.

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Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase

Abstract

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