TY - JOUR
T1 - Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase
AU - Bakhanashvili, Mary
AU - Novitsky, Elena
AU - Rubinstein, Ethan
AU - Levy, Itzchak
AU - Rahav, Galia
PY - 2005/4
Y1 - 2005/4
N2 - We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.
AB - We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs). A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.
UR - http://www.scopus.com/inward/record.url?scp=16244423293&partnerID=8YFLogxK
U2 - 10.1128/AAC.49.4.1576-1579.2005
DO - 10.1128/AAC.49.4.1576-1579.2005
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C2 - 15793143
AN - SCOPUS:16244423293
SN - 0066-4804
VL - 49
SP - 1576
EP - 1579
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 4
ER -