TY - GEN
T1 - Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems
AU - Abookasis, David
AU - Shemesh, David
AU - Bokobza, Naor
AU - Bloygrund, Hadas
AU - Franjy-Tal, Yarden
AU - Rozenberg, Konstantin
AU - Rosenzweig, Tovit
N1 - Publisher Copyright:
© 2020 SPIE.
PY - 2020
Y1 - 2020
N2 - In this work, we demonstrate the application of two optical imaging systems namely, dual-wavelength laser speckle and integrated spatial frequency domain imaging systems to image the changes in mouse brain tissue properties following acute hyperglycemia. We assume that hyperglycemia alters brain function which in turn can be monitored using these two optical modalities. Hyperglycemia was induced by intraperitoneal injection of an anesthetic ketamine and xylazine combination which is found to increase blood glucose more than threefold relative to normoglycemia. A total of ten mice were used, randomized into two groups of normoglycemia (n = 4) and hyperglycemia (n = 6). Experimental results demonstrated reductions in cerebral blood flow, tissue oxygen saturation, and cerebral metabolic rate of oxygen following acute hyperglycemia. In addition, differences in both cerebral tissue optical properties (absorption and scattering) with increasing glucose level were observed. Overall, experimental result demonstrates the capability of both systems to provide and map various brain tissue metrics following hyperglycemia.
AB - In this work, we demonstrate the application of two optical imaging systems namely, dual-wavelength laser speckle and integrated spatial frequency domain imaging systems to image the changes in mouse brain tissue properties following acute hyperglycemia. We assume that hyperglycemia alters brain function which in turn can be monitored using these two optical modalities. Hyperglycemia was induced by intraperitoneal injection of an anesthetic ketamine and xylazine combination which is found to increase blood glucose more than threefold relative to normoglycemia. A total of ten mice were used, randomized into two groups of normoglycemia (n = 4) and hyperglycemia (n = 6). Experimental results demonstrated reductions in cerebral blood flow, tissue oxygen saturation, and cerebral metabolic rate of oxygen following acute hyperglycemia. In addition, differences in both cerebral tissue optical properties (absorption and scattering) with increasing glucose level were observed. Overall, experimental result demonstrates the capability of both systems to provide and map various brain tissue metrics following hyperglycemia.
KW - Cerebral hemodynamics and metabolism
KW - Hyperglycemia
KW - Laser speckle imaging
KW - Optical properties
KW - Structured illumination
UR - http://www.scopus.com/inward/record.url?scp=85084190703&partnerID=8YFLogxK
U2 - 10.1117/12.2551867
DO - 10.1117/12.2551867
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AN - SCOPUS:85084190703
T3 - Proceedings of SPIE - The International Society for Optical Engineering
BT - Neurophotonics
A2 - Pavone, Francesco Saverio
A2 - Cognet, Laurent
A2 - Kuner, Thomas
PB - SPIE
T2 - Neurophotonics 2020
Y2 - 6 April 2020 through 10 April 2020
ER -