Evaluation the effect of acute hyperglycemia on cerebral tissue properties with diffuse optical imaging systems

David Abookasis, David Shemesh, Naor Bokobza, Hadas Bloygrund, Yarden Franjy-Tal, Konstantin Rozenberg, Tovit Rosenzweig

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

In this work, we demonstrate the application of two optical imaging systems namely, dual-wavelength laser speckle and integrated spatial frequency domain imaging systems to image the changes in mouse brain tissue properties following acute hyperglycemia. We assume that hyperglycemia alters brain function which in turn can be monitored using these two optical modalities. Hyperglycemia was induced by intraperitoneal injection of an anesthetic ketamine and xylazine combination which is found to increase blood glucose more than threefold relative to normoglycemia. A total of ten mice were used, randomized into two groups of normoglycemia (n = 4) and hyperglycemia (n = 6). Experimental results demonstrated reductions in cerebral blood flow, tissue oxygen saturation, and cerebral metabolic rate of oxygen following acute hyperglycemia. In addition, differences in both cerebral tissue optical properties (absorption and scattering) with increasing glucose level were observed. Overall, experimental result demonstrates the capability of both systems to provide and map various brain tissue metrics following hyperglycemia.

Original languageEnglish
Title of host publicationNeurophotonics
EditorsFrancesco Saverio Pavone, Laurent Cognet, Thomas Kuner
PublisherSPIE
ISBN (Electronic)9781510634923
DOIs
StatePublished - 2020
EventNeurophotonics 2020 - none, France
Duration: 6 Apr 202010 Apr 2020

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11360
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceNeurophotonics 2020
Country/TerritoryFrance
Citynone
Period6/04/2010/04/20

Keywords

  • Cerebral hemodynamics and metabolism
  • Hyperglycemia
  • Laser speckle imaging
  • Optical properties
  • Structured illumination

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