TY - JOUR
T1 - Evaluation of therapeutic drug monitoring of methotrexate in saliva of children with rheumatic diseases
AU - Press, Joseph
AU - Berkovitch, Matitiahu
AU - Laxer, Ron
AU - Giesbrecht, Esther
AU - Silverman, Earl
AU - Klein, Julia
AU - Koren, Gideon
PY - 1995/6
Y1 - 1995/6
N2 - Pediatric patients with leukemia, other malignancies, and rheumatological disease receive methotrexate chronically. Because of the documented correlation between methotrexate levels of compliance and clinical outcome, it is conceivable to verify appropriate systemic exposure to the drug. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is ethically limited. Our study shows poor correlation between serum total/free methotrexate concentrations and saliva levels, precluding the clinical use of this test.
AB - Pediatric patients with leukemia, other malignancies, and rheumatological disease receive methotrexate chronically. Because of the documented correlation between methotrexate levels of compliance and clinical outcome, it is conceivable to verify appropriate systemic exposure to the drug. Saliva sampling may be of potential interest, especially in children, in whom blood sampling is ethically limited. Our study shows poor correlation between serum total/free methotrexate concentrations and saliva levels, precluding the clinical use of this test.
KW - Children
KW - Methotrexate
KW - Rheumatological disease
KW - Saliva sampling
UR - http://www.scopus.com/inward/record.url?scp=0029007254&partnerID=8YFLogxK
U2 - 10.1097/00007691-199506000-00006
DO - 10.1097/00007691-199506000-00006
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C2 - 7624920
AN - SCOPUS:0029007254
SN - 0163-4356
VL - 17
SP - 247
EP - 250
JO - Therapeutic Drug Monitoring
JF - Therapeutic Drug Monitoring
IS - 3
ER -