Evaluation of the analgesic efficacy of floctafenine - A meta-analysis

P. Burtin, I. U. Qamar, C. Eliopoulos, A. Taddio, F. Fassos, T. R. Einarson, G. Koren

Research output: Contribution to journalArticlepeer-review


Floctafenine is a peripherally-acting nonsteroidal anti-inflammatory agent (NSAID) of the quinoline class, characterized by good clinical tolerance but somewhat limited data regarding analgesic efficacy. A review was made of all published controlled clinical trials of floctafenine, and the results of similar studies were combined using meta-analysis. From an overall total of 34 floctafenine trials, the results of 5 placebo-controlled studies, 4 comparing floctafenine with ASA, and 4 with codeine derivatives were able to be combined for purposes of this meta-analysis. In these studies, floctafenine provided good to excellent analgesia in 60-70% of patients with acute dental or postoperative pain, and in 30% of patients with severe chronic pain. Floctafenine was significantly more effective than placebo, as effective as ASA, and equally or more effective than codeine derivatives at the tested dosages.

Original languageEnglish
Pages (from-to)143-156
Number of pages14
JournalToday's Therapeutic Trends
Issue number3
StatePublished - 1993
Externally publishedYes


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