TY - JOUR
T1 - Establishing causality in pediatric adverse drug reactions
T2 - Use of the Naranjo probability scale
AU - Avner, Marina
AU - Finkelstein, Yaron
AU - Hackam, Dan
AU - Koren, Gideon
N1 - Funding Information:
Yaron Finkelstein is a recipient of a Fellowship of the Research Institute Training Center, Hospital for Sick Children, Toronto, Canada and the Tel Aviv University – Hospital for Sick Children Exchange Program. Gideon Koren is the holder of the Ivey Chair in Molecular Toxicology, The University of Western Ontario, London, ON, Canada. No sources of funding were used to assist in the preparation of this article. The authors have no conflicts of interest that are directly relevant to the content of this article.
PY - 2007
Y1 - 2007
N2 - Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition. Its diagnosis is critical to avoid future exposure to aromatic anticonvulsants. Pediatricians rarely use a systematic approach to establish the cause of drug reactions in the clinical setting. We describe the use of the Naranjo adverse drug reaction probability scale to establish causality in three cases of suspected anticonvulsant hypersensitivity syndrome with the aim of introducing clinicians to this effective tool. Our analysis reveals that this method is useful, but also highlights potential areas for its improvement.
AB - Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition. Its diagnosis is critical to avoid future exposure to aromatic anticonvulsants. Pediatricians rarely use a systematic approach to establish the cause of drug reactions in the clinical setting. We describe the use of the Naranjo adverse drug reaction probability scale to establish causality in three cases of suspected anticonvulsant hypersensitivity syndrome with the aim of introducing clinicians to this effective tool. Our analysis reveals that this method is useful, but also highlights potential areas for its improvement.
UR - http://www.scopus.com/inward/record.url?scp=34548067392&partnerID=8YFLogxK
U2 - 10.2165/00148581-200709040-00007
DO - 10.2165/00148581-200709040-00007
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C2 - 17705565
AN - SCOPUS:34548067392
SN - 1174-5878
VL - 9
SP - 267
EP - 270
JO - Paediatric Drugs
JF - Paediatric Drugs
IS - 4
ER -