TY - JOUR
T1 - Epstein-Barr virus infection in pregnancy-A prospective controlled study
AU - Avgil, Meytal
AU - Diav-Citrin, Orna
AU - Shechtman, Svetlana
AU - Arnon, Judy
AU - Wajnberg, Rebecka
AU - Ornoy, Asher
PY - 2008/8
Y1 - 2008/8
N2 - Background: Epstein-Barr virus (EBV) is one of the most common human viruses. To date, there is limited information regarding the influence of maternal EBV infection on pregnancy outcome. Objective: Our aim was to examine the fetal safety of EBV infection in pregnancy. Study design: We prospectively evaluated the rate of major anomalies and pregnancy outcome of women with serologic evidence of primary, recurrent or undefined infection (27, 56, and 43 women, respectively) compared to 1434 women who called the Israeli TIS for non-teratogenic exposure. Results: Women's characteristics and pregnancy outcome were comparable between the EBV exposed and control groups. Similarly, the gestational age at delivery and birth weight were not significantly different. The rate of major congenital anomalies did not significantly differ between the EBV exposed compared to the control group. Conclusion: This study suggests that EBV infection during pregnancy does not represent a major teratogenic risk to the fetus.
AB - Background: Epstein-Barr virus (EBV) is one of the most common human viruses. To date, there is limited information regarding the influence of maternal EBV infection on pregnancy outcome. Objective: Our aim was to examine the fetal safety of EBV infection in pregnancy. Study design: We prospectively evaluated the rate of major anomalies and pregnancy outcome of women with serologic evidence of primary, recurrent or undefined infection (27, 56, and 43 women, respectively) compared to 1434 women who called the Israeli TIS for non-teratogenic exposure. Results: Women's characteristics and pregnancy outcome were comparable between the EBV exposed and control groups. Similarly, the gestational age at delivery and birth weight were not significantly different. The rate of major congenital anomalies did not significantly differ between the EBV exposed compared to the control group. Conclusion: This study suggests that EBV infection during pregnancy does not represent a major teratogenic risk to the fetus.
KW - Congenital anomalies
KW - EBV
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=47249134938&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2008.04.004
DO - 10.1016/j.reprotox.2008.04.004
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C2 - 18534816
AN - SCOPUS:47249134938
SN - 0890-6238
VL - 25
SP - 468
EP - 471
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 4
ER -