Enantioselective metabolism of ifosfamide by the kidney

Katarina Aleksa, Shinya Ito, Gideon Koren

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Ifosfamide (IF), a potent chemotherapeutic agent for solid tumors, is known to cause high rates of nephrotoxicity, which is most likely due to the renal production of the metabolite chloroacetaldehyde. Enantioselective oxidation of IF has been shown in the liver but has never been reported in the kidney. Using porcine and human kidney samples, as well as the renal porcine cell line LLCPK-1, we document enantioselective metabolism of IF with prevalent production of the N-dechloroethylifosfamide (DCEIF) metabolites from the (S)-IF enantiomer compared to the amount of N-DCEIF metabolites produced from the (R)-IF enantiomers. Since IF enantiomers appear to be equally effective in chemotherapy, these results suggest that replacing the clinically standard racemic mixture of IF with (R)-IF may decrease renal metabolism of the drug and hence may decrease nephrotoxicity.

Original languageEnglish
Pages (from-to)398-405
Number of pages8
Issue number6
StatePublished - 2006
Externally publishedYes


  • CYP2B6
  • CYP3A
  • Enantioselective metabolism
  • Ifosfamide
  • Kidney
  • Nephrotoxicity


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