TY - JOUR
T1 - Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency
AU - Wolf, D. G.
AU - Yaniv, I.
AU - Ashkenazi, S.
AU - Honigman, A.
PY - 2001
Y1 - 2001
N2 - Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.
AB - Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.
UR - http://www.scopus.com/inward/record.url?scp=0035141743&partnerID=8YFLogxK
U2 - 10.1128/AAC.45.2.593-595.2001
DO - 10.1128/AAC.45.2.593-595.2001
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C2 - 11158760
AN - SCOPUS:0035141743
SN - 0066-4804
VL - 45
SP - 593
EP - 595
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 2
ER -