Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency

D. G. Wolf, I. Yaniv, S. Ashkenazi, A. Honigman

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. These unique findings may be related to the nature of the immunodeficiency in the SCID patient.

Original languageEnglish
Pages (from-to)593-595
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Dive into the research topics of 'Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency'. Together they form a unique fingerprint.

Cite this