Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital

Azita Leavitt; Shiri Navon-Venezia; Inna Chmelnitsky; Mitchell J. Schwaber; Yehuda Carmeli

doi:10.1128/AAC.00299-07

Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital

Azita Leavitt
, Shiri Navon-Venezia
, Inna Chmelnitsky
, Mitchell J. Schwaber
, Yehuda Carmeli

Research output: Contribution to journal › Article › peer-review

239 Scopus citations

Abstract

Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the bla_KPC-3 gene, while almost all other clones carried the bla_KPC-2 gene. This rapid dissemination of KPC outside the United States is worrisome.

Original language	English
Pages (from-to)	3026-3029
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00299-07
State	Published - Aug 2007
Externally published	Yes

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abstract = "Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the blaKPC-3 gene, while almost all other clones carried the blaKPC-2 gene. This rapid dissemination of KPC outside the United States is worrisome.",

author = "Azita Leavitt and Shiri Navon-Venezia and Inna Chmelnitsky and Schwaber, \{Mitchell J.\} and Yehuda Carmeli",

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AU - Chmelnitsky, Inna

AU - Schwaber, Mitchell J.

AU - Carmeli, Yehuda

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AB - Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the blaKPC-3 gene, while almost all other clones carried the blaKPC-2 gene. This rapid dissemination of KPC outside the United States is worrisome.

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Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital

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