Effects of Vicoprofen® and ibuprofen on anaerobic performance after muscle damage

William J. Kraemer, Ana L. Gómez, Nicholas A. Ratamess, Jay R. Hoffman, Jeff S. Volek, Martyn R. Rubin, Timothy P. Scheett, Michael R. McGuigan, Duncan French, Jaci L. VanHeest, Robbin B. Wickham, Brandon Doan, Scott A. Mazzetti, Robert U. Newton, Carl M. Maresh

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objective: To determine the effects of Vicoprofen®, ibuprofen, and placebo on anaerobic performance and pain relief after resistance-exercise-induced muscle damage. Design: Randomized, controlled clinical study. Setting: University human-performance/ sports-medicine laboratory. Participants: 36 healthy men. Methods and Measures: After baseline testing (72 h), participants performed an eccentric-exercise protocol. Each was evaluated for pain 24 h later and randomly assigned to a Vicoprofen (VIC), ibuprofen (IBU), or placebo (P) group. Postexercise testing was performed every 24 h for 4 d. Results: Significantly greater muscle force, power, and total work were observed in VIC than in P (P<.05) for most time points and for IBU at 48 h. Conclusions: Anaerobic performance is enhanced with VIC, especially within the first 24 h after significant muscle-tissue damage. The greater performances observed at 48 h might be a result of less damage at this time point with VIC treatment.

Original languageEnglish
Pages (from-to)104-119
Number of pages16
JournalJournal of Sport Rehabilitation
Issue number2
StatePublished - 2002
Externally publishedYes


  • Force production
  • Injury
  • Medical therapy
  • Power


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