TY - JOUR
T1 - Effects of time-release caffeine containing supplement on metabolic rate, glycerol concentration and performance
AU - Gonzalez, Adam M.
AU - Hoffman, Jay R.
AU - Wells, Adam J.
AU - Mangine, Gerald T.
AU - Townsend, Jeremy R.
AU - Jajtner, Adam R.
AU - Wang, Ran
AU - Miramonti, Amelia A.
AU - Pruna, Gabriel J.
AU - LaMonica, Michael B.
AU - Bohner, Jonathan D.
AU - Hoffman, Mattan W.
AU - Oliveira, Leonardo P.
AU - Fukuda, David H.
AU - Fragala, Maren S.
AU - Stout, Jeffrey R.
N1 - Publisher Copyright:
© 2015, Journal of Sports Science and Medicine. All rights reserved.
PY - 2015
Y1 - 2015
N2 - This study compared caffeine pharmacokinetics, glycerol concentrations, metabolic rate, and performance measures following ingestion of a time-release caffeine containing supplement (TRCAF) versus a regular caffeine capsule (CAF) and a placebo (PL). Following a double-blind, placebo-controlled, randomized, cross-over design, ten males (25.9 ± 3.2 y) who regularly consume caffeine ingested capsules containing either TR-CAF, CAF, or PL. Blood draws and performance measures occurred at every hour over an 8-hour period. Plasma caffeine concentrations were significantly greater (p < 0.05) in CAF compared to TR-CAF during hours 2-5 and significantly greater (p = 0.042) in TR-CAF compared to CAF at hour 8. There were no significant differences between trials in glycerol concentrations (p = 0.86) or metabolic measures (p = 0.17-0.91). Physical reaction time was significantly improved for CAF at hour 5 (p=0.01) compared to PL. Average upper body reaction time was significantly improved for CAF and TR-CAF during hours 1-4 (p = 0.04 and p = 0.01, respectively) and over the 8-hour period (p = 0.04 and p = 0.001, respectively) compared to PL. Average upper body reaction time was also significantly improved for TR-CAF compared to PL during hours 5-8 (p = 0.004). TR-CAF and CAF showed distinct pharmacokinetics yielding modest effects on reaction time, yet did not alter glycerol concentration, metabolic measures, or other performance measures.
AB - This study compared caffeine pharmacokinetics, glycerol concentrations, metabolic rate, and performance measures following ingestion of a time-release caffeine containing supplement (TRCAF) versus a regular caffeine capsule (CAF) and a placebo (PL). Following a double-blind, placebo-controlled, randomized, cross-over design, ten males (25.9 ± 3.2 y) who regularly consume caffeine ingested capsules containing either TR-CAF, CAF, or PL. Blood draws and performance measures occurred at every hour over an 8-hour period. Plasma caffeine concentrations were significantly greater (p < 0.05) in CAF compared to TR-CAF during hours 2-5 and significantly greater (p = 0.042) in TR-CAF compared to CAF at hour 8. There were no significant differences between trials in glycerol concentrations (p = 0.86) or metabolic measures (p = 0.17-0.91). Physical reaction time was significantly improved for CAF at hour 5 (p=0.01) compared to PL. Average upper body reaction time was significantly improved for CAF and TR-CAF during hours 1-4 (p = 0.04 and p = 0.01, respectively) and over the 8-hour period (p = 0.04 and p = 0.001, respectively) compared to PL. Average upper body reaction time was also significantly improved for TR-CAF compared to PL during hours 5-8 (p = 0.004). TR-CAF and CAF showed distinct pharmacokinetics yielding modest effects on reaction time, yet did not alter glycerol concentration, metabolic measures, or other performance measures.
KW - Caffeine bioavailability
KW - Energy
KW - Multiple object tracking
KW - Pharmacokinetics
KW - Reaction time
KW - Sustained release caffeine
UR - http://www.scopus.com/inward/record.url?scp=84928988104&partnerID=8YFLogxK
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AN - SCOPUS:84928988104
SN - 1303-2968
VL - 14
SP - 322
EP - 332
JO - Journal of Sports Science and Medicine
JF - Journal of Sports Science and Medicine
IS - 2
ER -