Effects of selective serotonin reuptake inhibitors on sperm and male fertility

Lauren Riggin, Gideon Koren

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Question: Some of my male patients who are taking antidepressants are planning to become fathers. Do selective serotonin reuptake inhibitors (SSRIs) affect sperm, causing either decreased fertility or increased risk of congenital anomalies? Answer: There is limited evidence regarding paternal SSRI use before conception and its effects on reproductive outcomes; however, there might be some increased risk of subfertility based on animal studies and sperm-quality studies. There are insufficient data at this time to change prescribing practices of SSRIs in men who are hoping to become fathers.

Original languageEnglish
Pages (from-to)529-530
Number of pages2
JournalCanadian Family Physician
Issue number6
StatePublished - 1 Jun 2015
Externally publishedYes


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