Abstract
Objectives: To study the effect of extracorporeal membrane oxygenation (ECMO) on the pharmacokinetics of morphine in infants. Design: A prospective, comparative study of morphine pharmacokinetics during and after ECMO. Setting: The pediatric intensive care unit at a children's hospital. Patients: Seven infants, aged 1 day to 12 months, requiring ECMO. Intervention: Infusion of morphine. Measurement and Main Results: Steady- state concentrations of morphine were used to generate a morphine clearance rate. Plasma clearance rate of morphine increased from 0.574 ± 0.3 L/kg/hr to 1.058 ± 0.727 L/kg/hr after discontinuation of ECMO (p < .01). Two infants experienced a clinical picture consistent with opioid withdrawal. Conclusion: Infants requiring morphine after ECMO may require higher dose rates to maintain adequate sedation.
| Original language | English |
|---|---|
| Pages (from-to) | 1099-1101 |
| Number of pages | 3 |
| Journal | Critical Care Medicine |
| Volume | 22 |
| Issue number | 7 |
| DOIs | |
| State | Published - 1994 |
| Externally published | Yes |
Keywords
- critical illness
- drug metabolism
- extracorporeal membrane oxygenation
- infants
- intensive care unit, pediatric
- morphine
- opiates
- pharmacodynamics
- pharmacokinetics
- pharmacology
- sedation