Effect of β-alanine supplementation on carnosine and histidine content in the hippocampus of 14-month-old rats

Jay R. Hoffman, John A. Rathmacher, Jennifer Robinson, Yftach Gepner, Hagit Cohen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Carnosine and histidine content in the hippocampus of 14-month-old male rats was examined following 30 days of β-alanine supplementation. All animals were provided identical diets; however, 100 mg of β-alanine was mixed with glucomannan (80:20 blend) in the water of β-alanine supplemented animals. Hippocampal carnosine content was significantly greater (p = 0.005) for β-alanine compared with control, while no differences (p = 0.438) were noted in histidine content between groups. Results provide initial evidence that β-alanine supplementation increases carnosine content in the hippocampus of middle-aged rats, without compromising histidine content. β-Alanine supplementation increases hippocampal carnosine content without compromising histidine content in middle-aged rats.

Original languageEnglish
Pages (from-to)1112-1115
Number of pages4
JournalApplied Physiology, Nutrition and Metabolism
Volume44
Issue number10
DOIs
StatePublished - 2019

Keywords

  • Aging
  • Brain
  • Dietary intervention
  • Health
  • Middle-age
  • Nutrition

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