TY - JOUR
T1 - Early Childhood Shigellosis and Attention Deficit Hyperactivity Disorder
T2 - A Population-Based Cohort Study with a Prolonged Follow-up
AU - Merzon, Eugene
AU - Gutbir, Yuval
AU - Vinker, Shlomo
AU - Golan Cohen, Avivit
AU - Horwitz, Dana
AU - Ashkenazi, Shai
AU - Sadaka, Yair
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2021/11
Y1 - 2021/11
N2 - Background: Although the short-term neurological complications of Shigella spp. are well described, potential neuropsychiatric outcomes have not been studied yet. We investigated the association between early childhood shigellosis and subsequent ADHD. Methods: This is a retrospective population-based cohort. Using a large Health Maintenance Organization database, the prevalence of ADHD was investigated among children aged 5–18 years who underwent stool culture prior to the age of 3 years. Results: Of 52,761 children with a stool culture examined, 5,269 (9.98%) had Shigella-positive results. The rate of ADHD was 10.6% and 8.6% among children with Shigella-positive and Shigella-negative stool cultures, respectively (p <.001). Adjusted odds ratio for ADHD after controlling for gender and socioeconomic status was 1.21 (CI 1.13–1.29, p <.001). The younger the child was during Shigella gastroenteritis, the higher was the association with ADHD (p <.001). Conclusion: Early childhood shigellosis is associated with an increased rate of long-term ADHD.
AB - Background: Although the short-term neurological complications of Shigella spp. are well described, potential neuropsychiatric outcomes have not been studied yet. We investigated the association between early childhood shigellosis and subsequent ADHD. Methods: This is a retrospective population-based cohort. Using a large Health Maintenance Organization database, the prevalence of ADHD was investigated among children aged 5–18 years who underwent stool culture prior to the age of 3 years. Results: Of 52,761 children with a stool culture examined, 5,269 (9.98%) had Shigella-positive results. The rate of ADHD was 10.6% and 8.6% among children with Shigella-positive and Shigella-negative stool cultures, respectively (p <.001). Adjusted odds ratio for ADHD after controlling for gender and socioeconomic status was 1.21 (CI 1.13–1.29, p <.001). The younger the child was during Shigella gastroenteritis, the higher was the association with ADHD (p <.001). Conclusion: Early childhood shigellosis is associated with an increased rate of long-term ADHD.
KW - ADHD
KW - childhood shigellosis
KW - gastroenteritis
UR - http://www.scopus.com/inward/record.url?scp=85088388467&partnerID=8YFLogxK
U2 - 10.1177/1087054720940392
DO - 10.1177/1087054720940392
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C2 - 32698643
AN - SCOPUS:85088388467
SN - 1087-0547
VL - 25
SP - 1791
EP - 1800
JO - Journal of Attention Disorders
JF - Journal of Attention Disorders
IS - 13
ER -