TY - JOUR
T1 - Drug delivery platform comprising long-wavelength fluorogenic phenolo-cyanine dye for real-time monitoring of drug release
AU - Bokan, Maksym
AU - Gellerman, Gary
AU - Patsenker, Leonid D.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/12
Y1 - 2019/12
N2 - Drug delivery platforms comprising an anticancer drug bound to a fluorogenic dye are of great importance for theranostics and personalized medicine. The existing platforms suffer from insufficient water-solubility and, in addition, their emission lies in the short-wavelength spectral region, which is not suitable for probing in the body. Herein, water-soluble, fluorogenic phenolo-cyanine dyes were synthesized and bound to the anti-cancer drug chlorambucil by means of a biodegradable ester linker to form a novel NIR fluorescent, anticancer drug delivery platform. This platform exhibits no detectable fluorescence, but upon environment-mediated drug release brightly emits at 720 nm. The obtained platform contains reactive carboxylic functionality facilitating its labeling to a cancer-targeting carrier such as a peptide, antibody or nanoparticle and is therefore promising for cancer treatment applications.
AB - Drug delivery platforms comprising an anticancer drug bound to a fluorogenic dye are of great importance for theranostics and personalized medicine. The existing platforms suffer from insufficient water-solubility and, in addition, their emission lies in the short-wavelength spectral region, which is not suitable for probing in the body. Herein, water-soluble, fluorogenic phenolo-cyanine dyes were synthesized and bound to the anti-cancer drug chlorambucil by means of a biodegradable ester linker to form a novel NIR fluorescent, anticancer drug delivery platform. This platform exhibits no detectable fluorescence, but upon environment-mediated drug release brightly emits at 720 nm. The obtained platform contains reactive carboxylic functionality facilitating its labeling to a cancer-targeting carrier such as a peptide, antibody or nanoparticle and is therefore promising for cancer treatment applications.
KW - Anticancer drug
KW - Chlorambucil
KW - Fluorescence real-time monitoring
KW - Fluorogenic dyes
KW - Phenolo-cyanines
KW - Targeted drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85068516544&partnerID=8YFLogxK
U2 - 10.1016/j.dyepig.2019.107703
DO - 10.1016/j.dyepig.2019.107703
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AN - SCOPUS:85068516544
SN - 0143-7208
VL - 171
JO - Dyes and Pigments
JF - Dyes and Pigments
M1 - 107703
ER -