Dosimetry and preliminary human studies of 18F-5-fluorouracil

Jashovam Shani, David Young, Tuvia Schlesinger, Jan K. Siemsen, Rowan T. Chlebowski, Joseph R. Bateman, Walter Wolf

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30 Scopus citations


The relative distribution, metabolism and kinetics of 18F containing compounds, following administration of 18F-5-fluorouracil, has been proposed as a prognostic aid in predicting response to 5-fluorouracil chemotherapy. Because 18F has a relatively short physical half-life (t 1 2 = 110 min), and the distribution and kinetics of the radiolabeled 5-fluorouracil need to be studied over periods of time that range over several half-lives of the radionuclide, significant quantities of the labeled drug must be administered in order to obtain good counting statistics. The distribution of 18F, following injection of 18F-5-fluorouracil to rats and mice, has been well documented in our previous work. It appears that the distribution of 18F in humans, following administration of 18F-5-fluorouracil is similar to that in rats. We calculated the radiation dose according to the MIRD technique for the eleven main target organs for a reference man. The critical organs, according to these calculations, are the bladder wall, the kidney and the liver, receiving a radiation dose of 729, 184 and 114 mrad per mCi injected, respectively.

Original languageEnglish
Pages (from-to)25-31,33-35
JournalInternational Journal of Nuclear Medicine and Biology
Issue number1
StatePublished - 1982
Externally publishedYes


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