Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

R. Ben-Ami, G. Rahav, H. Elinav, I. Kassis, I. Shalit, T. Gottesman, O. Megged, M. Weinberger, P. Ciobotaro, P. Shitrit, G. Weber, A. Paz, D. Miron, I. Oren, J. Bishara, C. Block, N. Keller, D. P. Kontoyiannis, M. Giladi

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

Original languageEnglish
Pages (from-to)752-756
Number of pages5
JournalClinical Microbiology and Infection
Volume19
Issue number8
DOIs
StatePublished - Aug 2013
Externally publishedYes

Keywords

  • Candidaemia
  • Drug resistance
  • Epidemiology
  • Fluconazole

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