Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

R. Ben-Ami; G. Rahav; H. Elinav; I. Kassis; I. Shalit; T. Gottesman; O. Megged; M. Weinberger; P. Ciobotaro; P. Shitrit; G. Weber; A. Paz; D. Miron; I. Oren; J. Bishara; C. Block; N. Keller; D. P. Kontoyiannis; M. Giladi

doi:10.1111/1469-0691.12004

Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

R. Ben-Ami, G. Rahav, H. Elinav, I. Kassis, I. Shalit, T. Gottesman, O. Megged, M. Weinberger, P. Ciobotaro, P. Shitrit, G. Weber, A. Paz, D. Miron, I. Oren, J. Bishara, C. Block, N. Keller, D. P. Kontoyiannis, M. Giladi

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19 Scopus citations

Abstract

The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

Original language	English
Pages (from-to)	752-756
Number of pages	5
Journal	Clinical Microbiology and Infection
Volume	19
Issue number	8
DOIs	https://doi.org/10.1111/1469-0691.12004
State	Published - Aug 2013
Externally published	Yes

Keywords

Candidaemia
Drug resistance
Epidemiology
Fluconazole

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Ben-Ami, R., Rahav, G., Elinav, H., Kassis, I., Shalit, I., Gottesman, T., Megged, O., Weinberger, M., Ciobotaro, P., Shitrit, P., Weber, G., Paz, A., Miron, D., Oren, I., Bishara, J., Block, C., Keller, N., Kontoyiannis, D. P., & Giladi, M. (2013). Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel. Clinical Microbiology and Infection, 19(8), 752-756. https://doi.org/10.1111/1469-0691.12004

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title = "Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel",

abstract = "The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.",

keywords = "Candidaemia, Drug resistance, Epidemiology, Fluconazole",

author = "R. Ben-Ami and G. Rahav and H. Elinav and I. Kassis and I. Shalit and T. Gottesman and O. Megged and M. Weinberger and P. Ciobotaro and P. Shitrit and G. Weber and A. Paz and D. Miron and I. Oren and J. Bishara and C. Block and N. Keller and Kontoyiannis, {D. P.} and M. Giladi",

note = "Funding Information: This work was funded in part by a grant from Merck Sharp & Dohme Ltd, Israel and by the Israeli Society for Infectious Diseases. ",

year = "2013",

month = aug,

doi = "10.1111/1469-0691.12004",

language = "אנגלית",

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Ben-Ami, R, Rahav, G, Elinav, H, Kassis, I, Shalit, I, Gottesman, T, Megged, O, Weinberger, M, Ciobotaro, P, Shitrit, P, Weber, G, Paz, A, Miron, D, Oren, I, Bishara, J, Block, C, Keller, N, Kontoyiannis, DP & Giladi, M 2013, 'Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel', Clinical Microbiology and Infection, vol. 19, no. 8, pp. 752-756. https://doi.org/10.1111/1469-0691.12004

TY - JOUR

T1 - Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

AU - Ben-Ami, R.

AU - Rahav, G.

AU - Elinav, H.

AU - Kassis, I.

AU - Shalit, I.

AU - Gottesman, T.

AU - Megged, O.

AU - Weinberger, M.

AU - Ciobotaro, P.

AU - Shitrit, P.

AU - Weber, G.

AU - Paz, A.

AU - Miron, D.

AU - Oren, I.

AU - Bishara, J.

AU - Block, C.

AU - Keller, N.

AU - Kontoyiannis, D. P.

AU - Giladi, M.

N1 - Funding Information: This work was funded in part by a grant from Merck Sharp & Dohme Ltd, Israel and by the Israeli Society for Infectious Diseases.

PY - 2013/8

Y1 - 2013/8

N2 - The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

AB - The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.

KW - Candidaemia

KW - Drug resistance

KW - Epidemiology

KW - Fluconazole

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JO - Clinical Microbiology and Infection

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IS - 8

ER -

Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel

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Keywords

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