Digoxin-carvedilol interactions in children

Savithiri Ratnapalan; Kathryn Griffiths; Adriana Moldovan Costei; Lee Benson; Gideon Koren

doi:10.1067/mpd.2003.160

Digoxin-carvedilol interactions in children

Savithiri Ratnapalan
, Kathryn Griffiths
, Adriana Moldovan Costei
, Lee Benson
, Gideon Koren

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.

Original language	English
Pages (from-to)	572-574
Number of pages	3
Journal	Journal of Pediatrics
Volume	142
Issue number	5
DOIs	https://doi.org/10.1067/mpd.2003.160
State	Published - 1 May 2003
Externally published	Yes

Access to Document

10.1067/mpd.2003.160

Cite this

@article{c61f53c29e8e4609a0dad14beace07ed,

title = "Digoxin-carvedilol interactions in children",

abstract = "Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.",

author = "Savithiri Ratnapalan and Kathryn Griffiths and Costei, \{Adriana Moldovan\} and Lee Benson and Gideon Koren",

note = "Funding Information: Supported by a grant from the Canadian Institutes of Health Research. G. K. is a Senior Scientist with the Canadian Institutes of Health and Research. ",

year = "2003",

month = may,

day = "1",

doi = "10.1067/mpd.2003.160",

language = "אנגלית",

volume = "142",

pages = "572--574",

journal = "Journal of Pediatrics",

issn = "0022-3476",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Digoxin-carvedilol interactions in children

AU - Ratnapalan, Savithiri

AU - Griffiths, Kathryn

AU - Costei, Adriana Moldovan

AU - Benson, Lee

AU - Koren, Gideon

N1 - Funding Information: Supported by a grant from the Canadian Institutes of Health Research. G. K. is a Senior Scientist with the Canadian Institutes of Health and Research.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.

AB - Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.

UR - https://www.scopus.com/pages/publications/0038358256

U2 - 10.1067/mpd.2003.160

DO - 10.1067/mpd.2003.160

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 12756393

AN - SCOPUS:0038358256

SN - 0022-3476

VL - 142

SP - 572

EP - 574

JO - Journal of Pediatrics

JF - Journal of Pediatrics

IS - 5

ER -

Digoxin-carvedilol interactions in children

Abstract

Access to Document

Other files and links

Fingerprint

Cite this