TY - JOUR
T1 - Digoxin-carvedilol interactions in children
AU - Ratnapalan, Savithiri
AU - Griffiths, Kathryn
AU - Costei, Adriana Moldovan
AU - Benson, Lee
AU - Koren, Gideon
N1 - Funding Information:
Supported by a grant from the Canadian Institutes of Health Research. G. K. is a Senior Scientist with the Canadian Institutes of Health and Research.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.
AB - Digoxin is often coadministered with carvedilol in children with severe ventricular failure. In eight children (age 2 weeks to 8 years), the oral clearance of digoxin decreased by half with carvedilol, and two of them had digoxin toxicity. Carvedilol increases serum concentrations of digoxin in children, and its dose may need to be reduced to avoid toxicity.
UR - http://www.scopus.com/inward/record.url?scp=0038358256&partnerID=8YFLogxK
U2 - 10.1067/mpd.2003.160
DO - 10.1067/mpd.2003.160
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C2 - 12756393
AN - SCOPUS:0038358256
SN - 0022-3476
VL - 142
SP - 572
EP - 574
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -