Abstract
Reported herein is the detection of anabolic steroids through the use of cyclodextrin-promoted interactions between the analyte of interest and a high quantum yield fluorophore, which lead to measurable, analyte-specific changes in the fluorophore emission signal. By using a variety of β-cyclodextrin derivatives (unmodified β-cyclodextrin, methyl-β-cyclodextrin, and 2-hydroxypropyl-β-cyclodextrin) in combination with high quantum yield fluorophore rhodamine 6G, we detected five anabolic steroid analytes with 100% differentiation between structurally similar analytes and micromolar level limits of detection. Overall, these results show significant potential in the development of practical, fluorescence-based steroid detection devices.
| Original language | English |
|---|---|
| Pages (from-to) | 25108-25115 |
| Number of pages | 8 |
| Journal | RSC Advances |
| Volume | 10 |
| Issue number | 42 |
| DOIs | |
| State | Published - 1 Jul 2020 |