Cyclodextrin-Promoted Detection of Aromatic Toxicants and Toxicant Metabolites in Urine

Dana J. DiScenza; Lauren Gareau; Nicole Serio; John Roque; Lindsey Prignano; Molly Verderame; Mindy Levine

doi:10.1080/22297928.2016.1210021

Cyclodextrin-Promoted Detection of Aromatic Toxicants and Toxicant Metabolites in Urine

Dana J. DiScenza, Lauren Gareau, Nicole Serio, John Roque, Lindsey Prignano, Molly Verderame, Mindy Levine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Reported herein is the development of a fluorescence-based detection method for aromatic toxicants and toxicant metabolites in urine, using cyclodextrin-promoted energy transfer to high quantumyield fluorophores. This method distinguishes smoker urine from non-smoker urine, enables highly accurate analyte identification, and leads to micromolar detection limits.

Original language	English
Pages (from-to)	345-353
Number of pages	9
Journal	Analytical Chemistry Letters
Volume	6
Issue number	4
DOIs	https://doi.org/10.1080/22297928.2016.1210021
State	Published - 2016
Externally published	Yes

Keywords

Cyclodextrin
fluorescence spectroscopy
polycyclic aromatic hydrocarbons

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10.1080/22297928.2016.1210021

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abstract = "Reported herein is the development of a fluorescence-based detection method for aromatic toxicants and toxicant metabolites in urine, using cyclodextrin-promoted energy transfer to high quantumyield fluorophores. This method distinguishes smoker urine from non-smoker urine, enables highly accurate analyte identification, and leads to micromolar detection limits.",

keywords = "Cyclodextrin, fluorescence spectroscopy, polycyclic aromatic hydrocarbons",

author = "DiScenza, {Dana J.} and Lauren Gareau and Nicole Serio and John Roque and Lindsey Prignano and Molly Verderame and Mindy Levine",

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doi = "10.1080/22297928.2016.1210021",

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AU - DiScenza, Dana J.

AU - Gareau, Lauren

AU - Serio, Nicole

AU - Roque, John

AU - Prignano, Lindsey

AU - Verderame, Molly

AU - Levine, Mindy

PY - 2016

Y1 - 2016

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AB - Reported herein is the development of a fluorescence-based detection method for aromatic toxicants and toxicant metabolites in urine, using cyclodextrin-promoted energy transfer to high quantumyield fluorophores. This method distinguishes smoker urine from non-smoker urine, enables highly accurate analyte identification, and leads to micromolar detection limits.

KW - Cyclodextrin

KW - fluorescence spectroscopy

KW - polycyclic aromatic hydrocarbons

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Cyclodextrin-Promoted Detection of Aromatic Toxicants and Toxicant Metabolites in Urine

Abstract

Keywords

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