Abstract
A pigmented melanocytic tumor was induced on the treated site of a C3H/HeN female mouse given repeated topical applications of 8-methoxy-psoralen and subsequent exposures to ultraviolet A radiation (PUVA) over a 7-month period. The tumor invaded the subcutaneous tissue and muscle but produced no distant metastases. To our knowledge, this is the first report suggesting a direct relationship between PUVA treatment and the induction of cutaneous melanocytic tumor in mice.
| Original language | English |
|---|---|
| Pages (from-to) | 28-31 |
| Number of pages | 4 |
| Journal | Photodermatology Photoimmunology and Photomedicine |
| Volume | 7 |
| Issue number | 1 |
| State | Published - 1990 |
| Externally published | Yes |