Cryptococcal meningitis in a child with hyperimmunoglobulin E syndrome

A 13‐year‐old boy with hyperimmunoglobulin E (hyper‐IgE) syndrome presented with headache, blurred vision, photophtobia and bilateral papilledema due to cryptococcal meningitis. Treatment with amphotericin B, and S‐fluorocytosine for several weeks and repeated lumbar punctures did not reduce the intracranial pressure, and a myeloperitoneal shunt was performed. The child was maintained on fluconazole for an additional six months. Patients with hyper‐IgE syndrome are at increased risk of opportunistic fungal infections such as cryptococcal meningitis.