Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of Diclectin (doxylamine-B6)

Raafat Bishai; Paul Mazzotta; Gordana Atanackovic; Zina Levichek; Meena Pole; Laura A. Magee; Gideon Koren

Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of Diclectin (doxylamine-B6)

Raafat Bishai, Paul Mazzotta, Gordana Atanackovic, Zina Levichek, Meena Pole, Laura A. Magee, Gideon Koren

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Nausea and vomiting of pregnancy is the most common condition in pregnancy and affects up to 80% of all pregnant women. There are a large number of pharmacological agents that are effective for the treatment of nausea and vomiting associated with conditions such as motion sickness and gastrointestinal conditions; however, their use in pregnancy is limited by the lack of sufficient data on their potential teratogenic effects. The efficacy of the delayed-release combination of doxylamine and pyridoxine (Bendectin, Diclectin) has been shown in several randomized, controlled trials. The present review aims to refute the unsubstantiated beliefs that Diclectin is unsafe when used in the treatment of nausea and vomiting of pregnancy.

Original language	English
Pages (from-to)	138-143
Number of pages	6
Journal	Journal of Population Therapeutics and Clinical Pharmacology
Volume	7
Issue number	3
State	Published - 2000
Externally published	Yes

Keywords

Doxylamine
Morning sickness
Nausea
Nausea and vomiting of pregnancy
Pregnancy
Pyridoxine
Vomiting

Cite this

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abstract = "Nausea and vomiting of pregnancy is the most common condition in pregnancy and affects up to 80% of all pregnant women. There are a large number of pharmacological agents that are effective for the treatment of nausea and vomiting associated with conditions such as motion sickness and gastrointestinal conditions; however, their use in pregnancy is limited by the lack of sufficient data on their potential teratogenic effects. The efficacy of the delayed-release combination of doxylamine and pyridoxine (Bendectin, Diclectin) has been shown in several randomized, controlled trials. The present review aims to refute the unsubstantiated beliefs that Diclectin is unsafe when used in the treatment of nausea and vomiting of pregnancy.",

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AU - Levichek, Zina

AU - Pole, Meena

AU - Magee, Laura A.

AU - Koren, Gideon

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Critical appraisal of drug therapy for nausea and vomiting of pregnancy: II. Efficacy and safety of Diclectin (doxylamine-B6)

Abstract

Keywords

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