Coupling the folding of homologous proteins

C. Keasar, D. Tobi, R. Elber, J. Skolnick

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The empirical observation that homologous proteins fold to similar structures is used to enhance the capabilities of an ab initio algorithm to predict protein conformations. A penalty function that forces homologous proteins to look alike is added to the potential and is employed in the coupled energy optimization of several homologous proteins. Significant improvement in the quality of the computed structures (as compared with the computational folding of a single protein) is demonstrated and discussed.

Original languageEnglish
Pages (from-to)5880-5883
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number11
StatePublished - 26 May 1998
Externally publishedYes


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