TY - JOUR
T1 - Cost-benefit analysis of active vaccination campaigns against hepatitis A among daycare centre personnel in Israel
AU - Chodick, Gabriel
AU - Lerman, Yehuda
AU - Peled, Tamar
AU - Aloni, Hava
AU - Ashkenazi, Shai
N1 - Funding Information:
The authors wish to thank Dr Andrea K. Biddle, Dr Ya-Chen Tina Shin, Mrs Elinor C.G. Chumney and Mr David Harrison from the School of Public Health, University of North Carolina at Chapel Hill, North Carolina, USA, for their most valuable assistance; Dr Gary M. Ginsberg for supplying most valuable data; and the Fulbright US-Israel Mutual Educational Fund for its financial support.
PY - 2001
Y1 - 2001
N2 - Objective: To evaluate, in economic terms, active vaccination campaigns against hepatitis A in comparison with the use of nonspecific immune globulin for the prevention of the disease among daycare centre employees in Israel. Setting: Hypothetical analysis of the costs and benefits related to vaccination campaigns of workers currently employed in daycare centres in Israel. Methods: A cost-benefit analysis was performed, comparing mass and selective active vaccination strategies for the daycare centre working force. Direct and indirect costs of diagnosis, treatment and immunisation as well as productivity loss were considered. A Markov-based model was developed using data from previous epidemiological studies and literature. Results: The benefit-to-cost ratios of selective and mass active vaccination strategies were 1.50 [net present value (NPV) $US606 396] and 0.04 (NPV-$US2.36 million), respectively (2000 values). Conclusion: Under these study assumptions, the practice of administering hepatitis A active vaccine to serologically proven non-immune daycare centre workers has a cost-benefit justification, and should be widely considered in countries with a similar hepatitis A epidemiology to that in this study.
AB - Objective: To evaluate, in economic terms, active vaccination campaigns against hepatitis A in comparison with the use of nonspecific immune globulin for the prevention of the disease among daycare centre employees in Israel. Setting: Hypothetical analysis of the costs and benefits related to vaccination campaigns of workers currently employed in daycare centres in Israel. Methods: A cost-benefit analysis was performed, comparing mass and selective active vaccination strategies for the daycare centre working force. Direct and indirect costs of diagnosis, treatment and immunisation as well as productivity loss were considered. A Markov-based model was developed using data from previous epidemiological studies and literature. Results: The benefit-to-cost ratios of selective and mass active vaccination strategies were 1.50 [net present value (NPV) $US606 396] and 0.04 (NPV-$US2.36 million), respectively (2000 values). Conclusion: Under these study assumptions, the practice of administering hepatitis A active vaccine to serologically proven non-immune daycare centre workers has a cost-benefit justification, and should be widely considered in countries with a similar hepatitis A epidemiology to that in this study.
UR - http://www.scopus.com/inward/record.url?scp=0035082144&partnerID=8YFLogxK
U2 - 10.2165/00019053-200119030-00006
DO - 10.2165/00019053-200119030-00006
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C2 - 11303416
AN - SCOPUS:0035082144
SN - 1170-7690
VL - 19
SP - 281
EP - 291
JO - PharmacoEconomics
JF - PharmacoEconomics
IS - 3
ER -