Controlled-release systems for the delivery of cyromazine into water surface

Liliana Schwartz, David Wolf, Arie Markus, Sławomir Wybraniec, Zeev Wiesman

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Controlled-release systems (CRSs) for the insect growth regulator cyromazine (Neporex), as a larvicide against Culex pipiens (Culicidae) mosquitoes, are under development. Despite promising results obtained previously for both in vitro (dissolution tests) and in vivo systems (mosquito larvae floating on water surfaces), it was evident that the CRSs did not remain afloat for sufficiently long times. The present study was thus conducted to determine the relationship between the process parameters and the potential contact time of the active ingredient with the mosquito larvae. A series of CRSs were prepared by an extrusion process, alone or in combination with a supplementary coating. The active ingredient was incorporated into the matrix or the coating. The matrix comprised low-density polyethylene 600 and perlite, and the coating, a polyurea with or without the addition of paraffin wax. The study showed that the cumulative release of the active ingredient into water could be controlled by manipulating the preparation techniques, the types and concentrations of inert materials, and the concentration of the active ingredient.

Original languageEnglish
Pages (from-to)5972-5976
Number of pages5
JournalJournal of Agricultural and Food Chemistry
Issue number20
StatePublished - 24 Sep 2003
Externally publishedYes


  • Coating
  • Controlled-release systems
  • Cyromazine
  • Encapsulation
  • Insect growth regulators
  • Matrix
  • Neporex
  • Pesticide formulations


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