Comparison of low- and high-intensity resistance exercise on lipid peroxidation: Role of muscle oxygenation

Jay R. Hoffman, Joohee Im, Jie Kang, Carl M. Maresh, William J. Kraemer, Duncan French, Shoko Nioka, Ryotaro Kime, Kenneth W. Rundell, Nicholas A. Ratamess, Avery D. Faigenbaum, Britton Chance

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38 Scopus citations


The purpose of this study was to examine the effect of low- vs. high-intensity resistance exercise on lipid peroxidation. In addition, the role of muscle oxygenation on plasma malondialdehyde (MDA) concentrations was explored. Eleven experienced resistance trained male athletes (age: 20.8 ± 1.3 years; weight: 96.2 ± 14.4 kg; height: 182.4 ± 7.3 cm) performed 4 sets of the squat exercise using either a low-intensity, high-volume (LI; 15 repetitions at 60% 1 repetition maximum [1RM]) or high-intensity, low-volume (HI; 4 repetitions at 90% 1RM load). Venous blood samples were obtained before the exercise (PRE), immediately following the exercise (IP), and 20 (20P) and 40 minutes (40P) postexercise. Continuous wave near-infrared spectroscopy was used to measure muscle deoxygenation in the vastus lateralis during exercise. Deoxygenated Hb/Mb change was used to determine reoxygenation rate during recovery. No difference in MDA concentrations was seen between LI and HI at any time. Significant correlations were observed between plasma MDA concentrations at IP and the half-time recovery (T1/2 recovery) of muscle reoxygenation (r = 0.45) and between T1/2 recovery and the area under the curve for MDA concentrations (r = 0.44). Results suggest that increases in MDA occur independently of exercise intensity, but tissue acidosis may have a larger influence on MDA formation.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalJournal of Strength and Conditioning Research
Issue number1
StatePublished - Feb 2007
Externally publishedYes


  • Athletes
  • Malondialdehyde
  • Near-infrared spectroscopy
  • Oxidative stress
  • Weight training


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