Colorimetric Detection of Aliphatic Alcohols in β-Cyclodextrin Solutions

Anna Haynes, Priva Halpert, Mindy Levine

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The sensitive, selective, and practical detection of aliphatic alcohols is a continuing technical challenge with significant impact in public health research and environmental remediation efforts. Reported herein is the use of a β-cyclodextrin derivative to promote proximity-induced interactions between aliphatic alcohol analytes and a brightly colored organic dye, which resulted in highly analyte-specific color changes that enabled accurate alcohol identification. Linear discriminant analysis of the color changes enabled 100% differentiation of the colorimetric signals obtained from methanol, ethanol, and isopropanol in combination with BODIPY and Rhodamine dyes. The resulting solution-state detection system has significant broad-based applicability because it uses only easily available materials to achieve such detection with moderate limits of detection obtained. Future research with this sensor system will focus on decreasing limits of detection as well as on optimizing the system for quantitative detection applications.

Original languageEnglish
Pages (from-to)18361-18369
Number of pages9
JournalACS Omega
Issue number19
StatePublished - 5 Nov 2019
Externally publishedYes


Dive into the research topics of 'Colorimetric Detection of Aliphatic Alcohols in β-Cyclodextrin Solutions'. Together they form a unique fingerprint.

Cite this