Cocaine inhibits hCG secretion by the human term placental cotyeedon perfused in vitro

Carmine Simone; Bridgette M. Byrne; Lidia O. Derewlany; Gideon Koren

doi:10.1016/0024-3205(95)02298-8

Cocaine inhibits hCG secretion by the human term placental cotyeedon perfused in vitro

Carmine Simone, Bridgette M. Byrne, Lidia O. Derewlany, Gideon Koren

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Cocaine has been shown to adversely affect pregnancy outcome in humans, but the mechanism(s) are not well understood. Using the technique of perfusing the human term placental cotyledon in vitro, we measured the rate of hCG appearance in the maternal circulation in the presence and absence of cocaine in the maternal circulation. At a dose of 0.80 μg/mL, hCG secretion was reduced by 46%. This reduction in hCG concentration in the maternal circulation may effect normal steroidogenesis required to maintain pregnancy and may contribute to our understanding of the reproductive toxicology of cocaine.

Original language	English
Pages (from-to)	PL63-PL66
Journal	Life Sciences
Volume	58
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(95)02298-8
State	Published - 22 Dec 1995
Externally published	Yes

Keywords

cocaine
hCG secretion
placenta

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10.1016/0024-3205(95)02298-8

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title = "Cocaine inhibits hCG secretion by the human term placental cotyeedon perfused in vitro",

abstract = "Cocaine has been shown to adversely affect pregnancy outcome in humans, but the mechanism(s) are not well understood. Using the technique of perfusing the human term placental cotyledon in vitro, we measured the rate of hCG appearance in the maternal circulation in the presence and absence of cocaine in the maternal circulation. At a dose of 0.80 μg/mL, hCG secretion was reduced by 46%. This reduction in hCG concentration in the maternal circulation may effect normal steroidogenesis required to maintain pregnancy and may contribute to our understanding of the reproductive toxicology of cocaine.",

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AU - Simone, Carmine

AU - Byrne, Bridgette M.

AU - Derewlany, Lidia O.

AU - Koren, Gideon

PY - 1995/12/22

Y1 - 1995/12/22

N2 - Cocaine has been shown to adversely affect pregnancy outcome in humans, but the mechanism(s) are not well understood. Using the technique of perfusing the human term placental cotyledon in vitro, we measured the rate of hCG appearance in the maternal circulation in the presence and absence of cocaine in the maternal circulation. At a dose of 0.80 μg/mL, hCG secretion was reduced by 46%. This reduction in hCG concentration in the maternal circulation may effect normal steroidogenesis required to maintain pregnancy and may contribute to our understanding of the reproductive toxicology of cocaine.

AB - Cocaine has been shown to adversely affect pregnancy outcome in humans, but the mechanism(s) are not well understood. Using the technique of perfusing the human term placental cotyledon in vitro, we measured the rate of hCG appearance in the maternal circulation in the presence and absence of cocaine in the maternal circulation. At a dose of 0.80 μg/mL, hCG secretion was reduced by 46%. This reduction in hCG concentration in the maternal circulation may effect normal steroidogenesis required to maintain pregnancy and may contribute to our understanding of the reproductive toxicology of cocaine.

KW - cocaine

KW - hCG secretion

KW - placenta

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Cocaine inhibits hCG secretion by the human term placental cotyeedon perfused in vitro

Abstract

Keywords

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