Clopidogrel use in children

Yaron Finkelstein, Laila Nurmohamed, Marina Avner, Lee N. Benson, Gideon Koren

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Objectives: To review a pediatric experience with the antiplatelet agent clopidogrel and suggest a dosage regimen. Study design: A retrospective chart review of all infants and children treated with clopidogrel at The Hospital for Sick Children, Toronto between January 2001 and April 2004. Clopidogrel dosages, duration of therapy, complications, and adverse effects in a pediatric population were explored. Results: Fifteen infants and children with congenital and acquired heart disease were treated with clopidogrel (median age, 3.5 years; range, 6 weeks to 16 years). Dosages ranged from 1 to 6 mg/kg/day for periods between 1 month and 6 months. Although no thrombotic events were reported, 1 child had a bleeding complication (gastrointestinal) while on triple antithrombotic therapy. Other complications reported in adults, including rash and clinical thrombocytopenia, were not noted in this pediatric series. Conclusions: Clopidogrel was well tolerated. We suggest a starting dose of 1 mg/kg/day for children.

Original languageEnglish
Pages (from-to)657-661
Number of pages5
JournalJournal of Pediatrics
Volume147
Issue number5
DOIs
StatePublished - Nov 2005
Externally publishedYes

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