Cisapride use during human pregnancy: A prospective, controlled multicenter study

Benoit Bailey; Antonio Addis; Amy Lee; Kinjal Sanghvi; Pierpaolo Mastroiacovo; Teresa Mazzone; Maurizo Bonati; Cinzia Paolini; Hanneke Garbis; Thierry Val; Carolina F.M. De Souza; Doren Matsui; Amy Stein Schechtman; Beth Conover; Melissa Lau; Gideon Koren

doi:10.1023/A:1018898707449

Cisapride use during human pregnancy: A prospective, controlled multicenter study

Benoit Bailey, Antonio Addis, Amy Lee, Kinjal Sanghvi, Pierpaolo Mastroiacovo, Teresa Mazzone, Maurizo Bonati, Cinzia Paolini, Hanneke Garbis, Thierry Val, Carolina F.M. De Souza, Doren Matsui, Amy Stein Schechtman, Beth Conover, Melissa Lau, Gideon Koren

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24 Scopus citations

Abstract

The objective of this prospective multicenter study was to determine whether cisapride is associated with increased risk of malformations, spontaneous abortions, or decreased birthweight when used during pregnancy. Cases were paired for age, smoking, and alcohol consumption with controls exposed to nonteratogens, as well as with disease-paired controls. One hundred and twenty-nine pregnant women were exposed to cisapride during pregnancy, including 88 during the period of fetal organogenesis. There were no differences in maternal history, birthweight, gestational age at delivery, and rates of livebirths, spontaneous or therapeutic abortions, fetal distress, and major or minor malformations among groups. It is concluded that exposure to cisapride during pregnancy is not associated with a major increased risk of malformations or spontaneous abortions or with decreased birthweight.

Original language	English
Pages (from-to)	1848-1852
Number of pages	5
Journal	Digestive Diseases and Sciences
Volume	42
Issue number	9
DOIs	https://doi.org/10.1023/A:1018898707449
State	Published - 1997
Externally published	Yes

Keywords

Cisapride
Drug-induced abnormality
Human
Pregnancy

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10.1023/A:1018898707449

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Bailey, B., Addis, A., Lee, A., Sanghvi, K., Mastroiacovo, P., Mazzone, T., Bonati, M., Paolini, C., Garbis, H., Val, T., De Souza, C. F. M., Matsui, D., Schechtman, A. S., Conover, B., Lau, M., & Koren, G. (1997). Cisapride use during human pregnancy: A prospective, controlled multicenter study. Digestive Diseases and Sciences, 42(9), 1848-1852. https://doi.org/10.1023/A:1018898707449

@article{ecbcacef6ab644e4b79d493ab380a64c,

title = "Cisapride use during human pregnancy: A prospective, controlled multicenter study",

abstract = "The objective of this prospective multicenter study was to determine whether cisapride is associated with increased risk of malformations, spontaneous abortions, or decreased birthweight when used during pregnancy. Cases were paired for age, smoking, and alcohol consumption with controls exposed to nonteratogens, as well as with disease-paired controls. One hundred and twenty-nine pregnant women were exposed to cisapride during pregnancy, including 88 during the period of fetal organogenesis. There were no differences in maternal history, birthweight, gestational age at delivery, and rates of livebirths, spontaneous or therapeutic abortions, fetal distress, and major or minor malformations among groups. It is concluded that exposure to cisapride during pregnancy is not associated with a major increased risk of malformations or spontaneous abortions or with decreased birthweight.",

keywords = "Cisapride, Drug-induced abnormality, Human, Pregnancy",

author = "Benoit Bailey and Antonio Addis and Amy Lee and Kinjal Sanghvi and Pierpaolo Mastroiacovo and Teresa Mazzone and Maurizo Bonati and Cinzia Paolini and Hanneke Garbis and Thierry Val and {De Souza}, {Carolina F.M.} and Doren Matsui and Schechtman, {Amy Stein} and Beth Conover and Melissa Lau and Gideon Koren",

note = "Funding Information: Supported by Jansse n Inc., Canada. Benoit Bailey was supported by a Canadian Society for Clinical Pharmacology Fellowship.",

year = "1997",

doi = "10.1023/A:1018898707449",

language = "אנגלית",

volume = "42",

pages = "1848--1852",

journal = "Digestive Diseases and Sciences",

issn = "0163-2116",

publisher = "Springer New York",

number = "9",

}

Bailey, B, Addis, A, Lee, A, Sanghvi, K, Mastroiacovo, P, Mazzone, T, Bonati, M, Paolini, C, Garbis, H, Val, T, De Souza, CFM, Matsui, D, Schechtman, AS, Conover, B, Lau, M & Koren, G 1997, 'Cisapride use during human pregnancy: A prospective, controlled multicenter study', Digestive Diseases and Sciences, vol. 42, no. 9, pp. 1848-1852. https://doi.org/10.1023/A:1018898707449

TY - JOUR

T1 - Cisapride use during human pregnancy

T2 - A prospective, controlled multicenter study

AU - Bailey, Benoit

AU - Addis, Antonio

AU - Lee, Amy

AU - Sanghvi, Kinjal

AU - Mastroiacovo, Pierpaolo

AU - Mazzone, Teresa

AU - Bonati, Maurizo

AU - Paolini, Cinzia

AU - Garbis, Hanneke

AU - Val, Thierry

AU - De Souza, Carolina F.M.

AU - Matsui, Doren

AU - Schechtman, Amy Stein

AU - Conover, Beth

AU - Lau, Melissa

AU - Koren, Gideon

N1 - Funding Information: Supported by Jansse n Inc., Canada. Benoit Bailey was supported by a Canadian Society for Clinical Pharmacology Fellowship.

PY - 1997

Y1 - 1997

N2 - The objective of this prospective multicenter study was to determine whether cisapride is associated with increased risk of malformations, spontaneous abortions, or decreased birthweight when used during pregnancy. Cases were paired for age, smoking, and alcohol consumption with controls exposed to nonteratogens, as well as with disease-paired controls. One hundred and twenty-nine pregnant women were exposed to cisapride during pregnancy, including 88 during the period of fetal organogenesis. There were no differences in maternal history, birthweight, gestational age at delivery, and rates of livebirths, spontaneous or therapeutic abortions, fetal distress, and major or minor malformations among groups. It is concluded that exposure to cisapride during pregnancy is not associated with a major increased risk of malformations or spontaneous abortions or with decreased birthweight.

AB - The objective of this prospective multicenter study was to determine whether cisapride is associated with increased risk of malformations, spontaneous abortions, or decreased birthweight when used during pregnancy. Cases were paired for age, smoking, and alcohol consumption with controls exposed to nonteratogens, as well as with disease-paired controls. One hundred and twenty-nine pregnant women were exposed to cisapride during pregnancy, including 88 during the period of fetal organogenesis. There were no differences in maternal history, birthweight, gestational age at delivery, and rates of livebirths, spontaneous or therapeutic abortions, fetal distress, and major or minor malformations among groups. It is concluded that exposure to cisapride during pregnancy is not associated with a major increased risk of malformations or spontaneous abortions or with decreased birthweight.

KW - Cisapride

KW - Drug-induced abnormality

KW - Human

KW - Pregnancy

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Cisapride use during human pregnancy: A prospective, controlled multicenter study

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Keywords

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