Cimetidine-related cardiac conduction disturbances and confusion

Natan Cohen, David Modai, Ahuva Golik, Moshe Eshkoly, Jacques Theitler, Eitan Scapa

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


A 70-year-old woman free of renal or hepatic dysfunction developed reversible mental confusion, sinus bradycardia, and extreme QT interval prolongation following initiation of intravenous cimetidine 1200 mg daily. The association of mental confusion with cardiac conduction impairment in a single patient in the context of cimetidine toxicity is highly unusual. We review this and other reports on potentially fatal cimetidine-related cardiac conduction disturbances to suggest that in patients at risk, in addition to reducing cimetidine dosage, electrocardiogram (ECG) follow-up is indicated to identify dangerous bradycardia and QT interval prolongation.

Original languageEnglish
Pages (from-to)68-69
Number of pages2
JournalJournal of Clinical Gastroenterology
Issue number1
StatePublished - Feb 1989
Externally publishedYes


  • Bradycardia
  • Cimetidine
  • Mental confusion
  • Prolonged QT interval


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