Chiral cationic polyamines for chiral microcapsules and siRNA delivery

Justin Gharavi, Patrick Marks, Kelly Moran, Brett Kingsborough, Ruchi Verma, Yuan Chen, Ruitang Deng, Mindy Levine

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Reported herein is the use of chiral cationic polyamines for two intriguing applications: fabrication of chiral covalently-linked microcapsules, and enantiospecific delivery of siRNA to Huh 7 cells. The microcapsules are easily fabricated from homochiral polymers, and the resulting architectures can be used for supramolecular chiral catalysis and many other potential applications. Enantiospecific delivery of siRNA to Huh 7 cells is seen by one 'enantiomer' of the polymers delivering siRNA with significantly improved transfection efficiency and reduced toxicity compared to the 'enantiomeric' polymer and commercially available transfection reagents. Taken together, the use of these easily accessible polyamine structures for diverse applications is highlighted in this Letter herein and can lead to numerous future research efforts.

Original languageEnglish
Pages (from-to)5919-5922
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume23
Issue number21
DOIs
StatePublished - 1 Nov 2013
Externally publishedYes

Keywords

  • Chirality
  • Polyamine
  • Transfection
  • siRNA

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