Chiral cationic polyamines for chiral microcapsules and siRNA delivery

Justin Gharavi; Patrick Marks; Kelly Moran; Brett Kingsborough; Ruchi Verma; Yuan Chen; Ruitang Deng; Mindy Levine

doi:10.1016/j.bmcl.2013.08.083

Chiral cationic polyamines for chiral microcapsules and siRNA delivery

Justin Gharavi, Patrick Marks, Kelly Moran, Brett Kingsborough, Ruchi Verma, Yuan Chen, Ruitang Deng, Mindy Levine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Reported herein is the use of chiral cationic polyamines for two intriguing applications: fabrication of chiral covalently-linked microcapsules, and enantiospecific delivery of siRNA to Huh 7 cells. The microcapsules are easily fabricated from homochiral polymers, and the resulting architectures can be used for supramolecular chiral catalysis and many other potential applications. Enantiospecific delivery of siRNA to Huh 7 cells is seen by one 'enantiomer' of the polymers delivering siRNA with significantly improved transfection efficiency and reduced toxicity compared to the 'enantiomeric' polymer and commercially available transfection reagents. Taken together, the use of these easily accessible polyamine structures for diverse applications is highlighted in this Letter herein and can lead to numerous future research efforts.

Original language	English
Pages (from-to)	5919-5922
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	21
DOIs	https://doi.org/10.1016/j.bmcl.2013.08.083
State	Published - 1 Nov 2013
Externally published	Yes

Keywords

Chirality
Polyamine
Transfection
siRNA

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10.1016/j.bmcl.2013.08.083

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title = "Chiral cationic polyamines for chiral microcapsules and siRNA delivery",

abstract = "Reported herein is the use of chiral cationic polyamines for two intriguing applications: fabrication of chiral covalently-linked microcapsules, and enantiospecific delivery of siRNA to Huh 7 cells. The microcapsules are easily fabricated from homochiral polymers, and the resulting architectures can be used for supramolecular chiral catalysis and many other potential applications. Enantiospecific delivery of siRNA to Huh 7 cells is seen by one 'enantiomer' of the polymers delivering siRNA with significantly improved transfection efficiency and reduced toxicity compared to the 'enantiomeric' polymer and commercially available transfection reagents. Taken together, the use of these easily accessible polyamine structures for diverse applications is highlighted in this Letter herein and can lead to numerous future research efforts.",

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note = "Funding Information: This work was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number 8 P20 GM103430-12 to M.L. R.D. is supported by the National Institutes of Health (NIH) (Grant No. R01DK087755 ). ",

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doi = "10.1016/j.bmcl.2013.08.083",

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AU - Gharavi, Justin

AU - Marks, Patrick

AU - Moran, Kelly

AU - Kingsborough, Brett

AU - Verma, Ruchi

AU - Chen, Yuan

AU - Deng, Ruitang

AU - Levine, Mindy

N1 - Funding Information: This work was supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under grant number 8 P20 GM103430-12 to M.L. R.D. is supported by the National Institutes of Health (NIH) (Grant No. R01DK087755 ).

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Reported herein is the use of chiral cationic polyamines for two intriguing applications: fabrication of chiral covalently-linked microcapsules, and enantiospecific delivery of siRNA to Huh 7 cells. The microcapsules are easily fabricated from homochiral polymers, and the resulting architectures can be used for supramolecular chiral catalysis and many other potential applications. Enantiospecific delivery of siRNA to Huh 7 cells is seen by one 'enantiomer' of the polymers delivering siRNA with significantly improved transfection efficiency and reduced toxicity compared to the 'enantiomeric' polymer and commercially available transfection reagents. Taken together, the use of these easily accessible polyamine structures for diverse applications is highlighted in this Letter herein and can lead to numerous future research efforts.

AB - Reported herein is the use of chiral cationic polyamines for two intriguing applications: fabrication of chiral covalently-linked microcapsules, and enantiospecific delivery of siRNA to Huh 7 cells. The microcapsules are easily fabricated from homochiral polymers, and the resulting architectures can be used for supramolecular chiral catalysis and many other potential applications. Enantiospecific delivery of siRNA to Huh 7 cells is seen by one 'enantiomer' of the polymers delivering siRNA with significantly improved transfection efficiency and reduced toxicity compared to the 'enantiomeric' polymer and commercially available transfection reagents. Taken together, the use of these easily accessible polyamine structures for diverse applications is highlighted in this Letter herein and can lead to numerous future research efforts.

KW - Chirality

KW - Polyamine

KW - Transfection

KW - siRNA

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Chiral cationic polyamines for chiral microcapsules and siRNA delivery

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