TY - JOUR
T1 - Cell surface expression of CD25 antigen (surface IL-2 receptor alpha-chain) is not a prognostic marker in chronic lymphocytic leukemia
T2 - Results of a retrospective study of 281 patients
AU - Shvidel, Lev
AU - Braester, Andrei
AU - Bairey, Osnat
AU - Rahimi-Levene, Naomi
AU - Herishanu, Yair
AU - Tadmor, Tamar
AU - Klepfish, Abraham
AU - Ruchlemer, Rosa
AU - Shtalrid, Mordechai
AU - Berrebi, Alain
AU - Polliack, Aaron
PY - 2012/10
Y1 - 2012/10
N2 - Using the database of the Israeli CLL Study Group, we investigated the incidence and prognostic significance of CD25 expression on the surface of lymphocytic leukemia cells. Strong CD25 expression was found in 46 (16.4 %) of 281 tested cases and was correlated with the presence of splenomegaly (p=0.04), expression of CD38 antigen (p=0.001), and FMC-7 (p=0.04). Age, gender, Binet stage, circulating lymphocyte count, presence of anemia or thrombocytopenia, atypical cell morphology, serum beta 2-microglobulin level, and ZAP-70 expression did not differ in patients with or without cell surface CD25. There was no correlation between CD25 expression and time to first treatment or overall survival. CD25 expression does not appear to be a prognostic factor in CLL.
AB - Using the database of the Israeli CLL Study Group, we investigated the incidence and prognostic significance of CD25 expression on the surface of lymphocytic leukemia cells. Strong CD25 expression was found in 46 (16.4 %) of 281 tested cases and was correlated with the presence of splenomegaly (p=0.04), expression of CD38 antigen (p=0.001), and FMC-7 (p=0.04). Age, gender, Binet stage, circulating lymphocyte count, presence of anemia or thrombocytopenia, atypical cell morphology, serum beta 2-microglobulin level, and ZAP-70 expression did not differ in patients with or without cell surface CD25. There was no correlation between CD25 expression and time to first treatment or overall survival. CD25 expression does not appear to be a prognostic factor in CLL.
KW - CD25
KW - Chronic lymphocytic leukemia
KW - CLL
KW - Flow cytometry
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=84867332612&partnerID=8YFLogxK
U2 - 10.1007/s00277-012-1492-4
DO - 10.1007/s00277-012-1492-4
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C2 - 22623161
AN - SCOPUS:84867332612
SN - 0939-5555
VL - 91
SP - 1597
EP - 1602
JO - Annals of Hematology
JF - Annals of Hematology
IS - 10
ER -