Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate

Erzsébet Illés; Amir Mizrahi; Vered Marks; Dan Meyerstein

doi:10.1016/j.freeradbiomed.2018.11.015

Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate

Erzsébet Illés, Amir Mizrahi, Vered Marks, Dan Meyerstein

Department of Chemical Sciences

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

The Fenton reaction, Fe(H₂O)₆ ²⁺ + H₂O₂ → Oxidizing product, is of major importance in biology as the major cause of oxidative stress, and in advanced oxidation processes. It is commonly assumed that ·OH is the product of the Fenton reaction. The results presented herein point out that ·OH is indeed the oxidizing product in acidic solutions for [Fe(H₂O)₆ ²⁺] > [H₂O₂]; Fe^IV _aq is the active oxidizing product in neutral solutions; in slightly acidic solutions for [H₂O₂] > [Fe(H₂O)₆ ²⁺] a mixture of ·OH and Fe^IV _aq is formed. However CO₃·^- is the active oxidizing product in neutral solutions containing HCO₃ ^- even at low concentrations, i.e. under physiological conditions. The implications to our understanding of the origins of oxidative stress and of catalytic oxidations in advanced oxidation processes are discussed.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Free Radical Biology and Medicine
Volume	131
DOIs	https://doi.org/10.1016/j.freeradbiomed.2018.11.015
State	Published - 1 Feb 2019

Keywords

Bicarbonate
Carbonate-radical-anion
Fenton reaction
Iron
Radicals

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10.1016/j.freeradbiomed.2018.11.015

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title = "Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate",

abstract = "The Fenton reaction, Fe(H2O)6 2+ + H2O2 → Oxidizing product, is of major importance in biology as the major cause of oxidative stress, and in advanced oxidation processes. It is commonly assumed that ·OH is the product of the Fenton reaction. The results presented herein point out that ·OH is indeed the oxidizing product in acidic solutions for [Fe(H2O)6 2+] > [H2O2]; FeIV aq is the active oxidizing product in neutral solutions; in slightly acidic solutions for [H2O2] > [Fe(H2O)6 2+] a mixture of ·OH and FeIV aq is formed. However CO3·- is the active oxidizing product in neutral solutions containing HCO3 - even at low concentrations, i.e. under physiological conditions. The implications to our understanding of the origins of oxidative stress and of catalytic oxidations in advanced oxidation processes are discussed.",

keywords = "Bicarbonate, Carbonate-radical-anion, Fenton reaction, Iron, Radicals",

author = "Erzs{\'e}bet Ill{\'e}s and Amir Mizrahi and Vered Marks and Dan Meyerstein",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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T1 - Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate

AU - Illés, Erzsébet

AU - Mizrahi, Amir

AU - Marks, Vered

AU - Meyerstein, Dan

PY - 2019/2/1

Y1 - 2019/2/1

N2 - The Fenton reaction, Fe(H2O)6 2+ + H2O2 → Oxidizing product, is of major importance in biology as the major cause of oxidative stress, and in advanced oxidation processes. It is commonly assumed that ·OH is the product of the Fenton reaction. The results presented herein point out that ·OH is indeed the oxidizing product in acidic solutions for [Fe(H2O)6 2+] > [H2O2]; FeIV aq is the active oxidizing product in neutral solutions; in slightly acidic solutions for [H2O2] > [Fe(H2O)6 2+] a mixture of ·OH and FeIV aq is formed. However CO3·- is the active oxidizing product in neutral solutions containing HCO3 - even at low concentrations, i.e. under physiological conditions. The implications to our understanding of the origins of oxidative stress and of catalytic oxidations in advanced oxidation processes are discussed.

AB - The Fenton reaction, Fe(H2O)6 2+ + H2O2 → Oxidizing product, is of major importance in biology as the major cause of oxidative stress, and in advanced oxidation processes. It is commonly assumed that ·OH is the product of the Fenton reaction. The results presented herein point out that ·OH is indeed the oxidizing product in acidic solutions for [Fe(H2O)6 2+] > [H2O2]; FeIV aq is the active oxidizing product in neutral solutions; in slightly acidic solutions for [H2O2] > [Fe(H2O)6 2+] a mixture of ·OH and FeIV aq is formed. However CO3·- is the active oxidizing product in neutral solutions containing HCO3 - even at low concentrations, i.e. under physiological conditions. The implications to our understanding of the origins of oxidative stress and of catalytic oxidations in advanced oxidation processes are discussed.

KW - Bicarbonate

KW - Carbonate-radical-anion

KW - Fenton reaction

KW - Iron

KW - Radicals

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SN - 0891-5849

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JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Carbonate-radical-anions, and not hydroxyl radicals, are the products of the Fenton reaction in neutral solutions containing bicarbonate

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Keywords

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