TY - JOUR
T1 - Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans
T2 - Embracing Putative Induction of Dopamine Homeostasis
AU - Blum, Kenneth
AU - Khalsa, Jag
AU - Cadet, Jean Lud
AU - Baron, David
AU - Bowirrat, Abdalla
AU - Boyett, Brent
AU - Lott, Lisa
AU - Brewer, Raymond
AU - Gondré-Lewis, Marjorie
AU - Bunt, Gregory
AU - Kazmi, Shan
AU - Gold, Mark S.
N1 - Publisher Copyright:
© Copyright © 2021 Blum, Khalsa, Cadet, Baron, Bowirrat, Boyett, Lott, Brewer, Gondré-Lewis, Bunt, Kazmi and Gold.
PY - 2021/3/30
Y1 - 2021/3/30
N2 - Over years, the regular use of cannabis has substantially increased among young adults, as indicated by the rise in cannabis use disorder (CUD), with an estimated prevalence of 8. 3% in the United States. Research shows that exposure to cannabis is associated with hypodopaminergic anhedonia (depression), cognitive decline, poor memory, inattention, impaired learning performance, reduced dopamine brain response-associated emotionality, and increased addiction severity in young adults. The addiction medicine community is increasing concern because of the high content of delta-9-tetrahydrocannabinol (THC) currently found in oral and vaping cannabis products, the cognitive effects of cannabis may become more pronounced in young adults who use these cannabis products. Preliminary research suggests that it is possible to induce 'dopamine homeostasis,' that is, restore dopamine function with dopamine upregulation with the proposed compound and normalize behavior in chronic cannabis users with cannabis-induced hypodopaminergic anhedonia (depression) and cognitive decline. This psychological, neurobiological, anatomical, genetic, and epigenetic research also could provide evidence to use for the development of an appropriate policy regarding the decriminalization of cannabis for recreational use.
AB - Over years, the regular use of cannabis has substantially increased among young adults, as indicated by the rise in cannabis use disorder (CUD), with an estimated prevalence of 8. 3% in the United States. Research shows that exposure to cannabis is associated with hypodopaminergic anhedonia (depression), cognitive decline, poor memory, inattention, impaired learning performance, reduced dopamine brain response-associated emotionality, and increased addiction severity in young adults. The addiction medicine community is increasing concern because of the high content of delta-9-tetrahydrocannabinol (THC) currently found in oral and vaping cannabis products, the cognitive effects of cannabis may become more pronounced in young adults who use these cannabis products. Preliminary research suggests that it is possible to induce 'dopamine homeostasis,' that is, restore dopamine function with dopamine upregulation with the proposed compound and normalize behavior in chronic cannabis users with cannabis-induced hypodopaminergic anhedonia (depression) and cognitive decline. This psychological, neurobiological, anatomical, genetic, and epigenetic research also could provide evidence to use for the development of an appropriate policy regarding the decriminalization of cannabis for recreational use.
KW - anhedonia
KW - cannabis use disorder
KW - depression
KW - dopamine homeostasis
KW - genetic testing
KW - neuroanatomic alterations
KW - pro-dopamine regulation
KW - reward deficiency syndrome
UR - http://www.scopus.com/inward/record.url?scp=85104029156&partnerID=8YFLogxK
U2 - 10.3389/fpsyt.2021.623403
DO - 10.3389/fpsyt.2021.623403
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AN - SCOPUS:85104029156
SN - 1664-0640
VL - 12
JO - Frontiers in Psychiatry
JF - Frontiers in Psychiatry
M1 - 623403
ER -