Candidate gene analysis in Israeli soldiers with stress fractures

Ran Yanovich, Eitan Friedman, Roni Milgrom, Bernice Oberman, Laurence Freedman, Daniel S. Moran

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


To investigate the association of polymorphisms within candidate genes which we hypothesized may contribute to stress fracture predisposition, a case-control, cross-sectional study design was employed. Genotyping 268 Single Nucleotide Polymorphisms-SNPs within 17 genes in 385 Israeli young male and female recruits (182 with and 203 without stress fractures). Twenty-five polymorphisms within 9 genes (NR3C1, ANKH, VDR, ROR2, CALCR, IL6, COL1A2, CBG, and LRP4) showed statistically significant differences (p < 0.05) in the distribution between stress fracture cases and non stress fracture controls. Seventeen genetic variants were associated with an increased stress fracture risk, and eight variants with a decreased stress fracture risk. None of the SNP associations remained significant after correcting for multiple comparisons (false discovery rate-FDR). Our findings suggest that genes may be involved in stress fracture pathogenesis. Specifically, the CALCR and the VDR genes are intriguing candidates. The putative involvement of these genes in stress fracture predisposition requires analysis of more cases and controls and sequencing the relevant genomic regions, in order to define the specific gene mutations.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalJournal of Sports Science and Medicine
Issue number1
StatePublished - Mar 2012


  • Bone remodeling
  • Genetic variance
  • Inherited predisposition
  • SNPs
  • Stress fractures


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