Can Venlafaxine in Breast Milk Attenuate the Norepinephrine and Serotonin Reuptake Neonatal Withdrawal Syndrome?

Gideon Koren, Myla Moretti, Bhushan Kapur

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

A newborn infant whose mother had used venlafaxine, a selective inhibitor of both norepinephrine and serotonin reuptake, throughout pregnancy exhibited signs consistent with the norepinephrine and serotonin reuptake withdrawal syndrome. Is it possible that mother's milk can help mitigate the effects of norepinephrine and serotonin reuptake withdrawal? Pharmacokinetic analysis and review of the only published case with active treatment of a baby with venlafaxine suggest that breastfeeding may mitigate the neonatal withdrawal syndrome.

Original languageEnglish
Pages (from-to)299-301
Number of pages3
JournalJournal of Obstetrics and Gynaecology Canada
Volume28
Issue number4
DOIs
StatePublished - 2006
Externally publishedYes

Keywords

  • Breast milk
  • Neonate
  • Norepinephrine reuptake inhibitor
  • Serotonin reuptake inhibitor
  • Substance withdrawal syndrome
  • Venlafaxine

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