C-terminal agrin fragment is inversely related to neuromuscular fatigue in older men

Jeffrey R. Stout; Maren S. Fragala; Jay R. Hoffman; Edward H. Robinson; William P. Mccormack; Jeremy R. Townsend; Adam R. Jatjner; Nadia S. Emerson; Leonardo P. Oliveira; David H. Fukuda

doi:10.1002/mus.24443

C-terminal agrin fragment is inversely related to neuromuscular fatigue in older men

Jeffrey R. Stout, Maren S. Fragala, Jay R. Hoffman, Edward H. Robinson, William P. Mccormack, Jeremy R. Townsend, Adam R. Jatjner, Nadia S. Emerson, Leonardo P. Oliveira, David H. Fukuda

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Introduction: The aim of this study was to examine the relationship between serum C-terminal agrin fragment (CAF) concentrations and neuromuscular fatigue in older adults. Methods: Twenty-two healthy older men and women volunteered for this study. Resting fasted blood samples were collected and prepared for measurement of serum CAF concentration by a commercially available ELISA kit. The onset of neuromuscular fatigue was measured by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at fatigue threshold (PWC_FT) test. Results: A significant inverse correlation for men was observed between CAF and PWC_FT (r=-0.602; P=0.05), but not for women (r=0.208; P=0.54). After controlling for age and body mass index, significant correlations (r=-0.69; P=0.042) remained for men, but not for women (r=0.12; P=0.76). Conclusions: These data suggest that serum CAF concentrations were significantly related to the onset of neuromuscular fatigue independent of age and BMI in men only.

Original language	English
Pages (from-to)	132-133
Number of pages	2
Journal	Muscle and Nerve
Volume	51
Issue number	1
DOIs	https://doi.org/10.1002/mus.24443
State	Published - 1 Jan 2015
Externally published	Yes

Keywords

Aging
Electromyography
Exercise
Physiological adaptations
Sarcopenia
Serum biomarker

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title = "C-terminal agrin fragment is inversely related to neuromuscular fatigue in older men",

abstract = "Introduction: The aim of this study was to examine the relationship between serum C-terminal agrin fragment (CAF) concentrations and neuromuscular fatigue in older adults. Methods: Twenty-two healthy older men and women volunteered for this study. Resting fasted blood samples were collected and prepared for measurement of serum CAF concentration by a commercially available ELISA kit. The onset of neuromuscular fatigue was measured by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at fatigue threshold (PWCFT) test. Results: A significant inverse correlation for men was observed between CAF and PWCFT (r=-0.602; P=0.05), but not for women (r=0.208; P=0.54). After controlling for age and body mass index, significant correlations (r=-0.69; P=0.042) remained for men, but not for women (r=0.12; P=0.76). Conclusions: These data suggest that serum CAF concentrations were significantly related to the onset of neuromuscular fatigue independent of age and BMI in men only.",

keywords = "Aging, Electromyography, Exercise, Physiological adaptations, Sarcopenia, Serum biomarker",

author = "Stout, {Jeffrey R.} and Fragala, {Maren S.} and Hoffman, {Jay R.} and Robinson, {Edward H.} and Mccormack, {William P.} and Townsend, {Jeremy R.} and Jatjner, {Adam R.} and Emerson, {Nadia S.} and Oliveira, {Leonardo P.} and Fukuda, {David H.}",

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year = "2015",

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doi = "10.1002/mus.24443",

language = "אנגלית",

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AU - Stout, Jeffrey R.

AU - Fragala, Maren S.

AU - Hoffman, Jay R.

AU - Robinson, Edward H.

AU - Mccormack, William P.

AU - Townsend, Jeremy R.

AU - Jatjner, Adam R.

AU - Emerson, Nadia S.

AU - Oliveira, Leonardo P.

AU - Fukuda, David H.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Introduction: The aim of this study was to examine the relationship between serum C-terminal agrin fragment (CAF) concentrations and neuromuscular fatigue in older adults. Methods: Twenty-two healthy older men and women volunteered for this study. Resting fasted blood samples were collected and prepared for measurement of serum CAF concentration by a commercially available ELISA kit. The onset of neuromuscular fatigue was measured by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at fatigue threshold (PWCFT) test. Results: A significant inverse correlation for men was observed between CAF and PWCFT (r=-0.602; P=0.05), but not for women (r=0.208; P=0.54). After controlling for age and body mass index, significant correlations (r=-0.69; P=0.042) remained for men, but not for women (r=0.12; P=0.76). Conclusions: These data suggest that serum CAF concentrations were significantly related to the onset of neuromuscular fatigue independent of age and BMI in men only.

AB - Introduction: The aim of this study was to examine the relationship between serum C-terminal agrin fragment (CAF) concentrations and neuromuscular fatigue in older adults. Methods: Twenty-two healthy older men and women volunteered for this study. Resting fasted blood samples were collected and prepared for measurement of serum CAF concentration by a commercially available ELISA kit. The onset of neuromuscular fatigue was measured by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at fatigue threshold (PWCFT) test. Results: A significant inverse correlation for men was observed between CAF and PWCFT (r=-0.602; P=0.05), but not for women (r=0.208; P=0.54). After controlling for age and body mass index, significant correlations (r=-0.69; P=0.042) remained for men, but not for women (r=0.12; P=0.76). Conclusions: These data suggest that serum CAF concentrations were significantly related to the onset of neuromuscular fatigue independent of age and BMI in men only.

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C-terminal agrin fragment is inversely related to neuromuscular fatigue in older men

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