Bright fluorogenic squaraines with tuned cell entry for selective imaging of plasma membrane vs. endoplasmic reticulum

Mayeul Collot; Rémy Kreder; Anatoliy L. Tatarets; Leonid D. Patsenker; Yves Mely; Andrey S. Klymchenko

doi:10.1039/c5cc06094j

Bright fluorogenic squaraines with tuned cell entry for selective imaging of plasma membrane vs. endoplasmic reticulum

Mayeul Collot
, Rémy Kreder
, Anatoliy L. Tatarets
, Leonid D. Patsenker
, Yves Mely
, Andrey S. Klymchenko

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

A rational design of squaraine dyes with lipophilic and zwitterionic groups tunes cell entry, allowing for selective far-red/near-infrared imaging of plasma membrane vs. endoplasmic reticulum. They exhibit up to 110-fold fluorescence enhancement in biomembranes and enable cellular imaging at 1 nM concentration, which make them the brightest membrane probes to date.

Original language	English
Pages (from-to)	17136-17139
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	96
DOIs	https://doi.org/10.1039/c5cc06094j
State	Published - 2015
Externally published	Yes

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10.1039/c5cc06094j

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abstract = "A rational design of squaraine dyes with lipophilic and zwitterionic groups tunes cell entry, allowing for selective far-red/near-infrared imaging of plasma membrane vs. endoplasmic reticulum. They exhibit up to 110-fold fluorescence enhancement in biomembranes and enable cellular imaging at 1 nM concentration, which make them the brightest membrane probes to date.",

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doi = "10.1039/c5cc06094j",

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AU - Collot, Mayeul

AU - Kreder, Rémy

AU - Tatarets, Anatoliy L.

AU - Patsenker, Leonid D.

AU - Mely, Yves

AU - Klymchenko, Andrey S.

PY - 2015

Y1 - 2015

N2 - A rational design of squaraine dyes with lipophilic and zwitterionic groups tunes cell entry, allowing for selective far-red/near-infrared imaging of plasma membrane vs. endoplasmic reticulum. They exhibit up to 110-fold fluorescence enhancement in biomembranes and enable cellular imaging at 1 nM concentration, which make them the brightest membrane probes to date.

AB - A rational design of squaraine dyes with lipophilic and zwitterionic groups tunes cell entry, allowing for selective far-red/near-infrared imaging of plasma membrane vs. endoplasmic reticulum. They exhibit up to 110-fold fluorescence enhancement in biomembranes and enable cellular imaging at 1 nM concentration, which make them the brightest membrane probes to date.

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Bright fluorogenic squaraines with tuned cell entry for selective imaging of plasma membrane vs. endoplasmic reticulum

Abstract

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