Bright fluorogenic squaraines with tuned cell entry for selective imaging of plasma membrane vs. endoplasmic reticulum

Mayeul Collot, Rémy Kreder, Anatoliy L. Tatarets, Leonid D. Patsenker, Yves Mely, Andrey S. Klymchenko

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

A rational design of squaraine dyes with lipophilic and zwitterionic groups tunes cell entry, allowing for selective far-red/near-infrared imaging of plasma membrane vs. endoplasmic reticulum. They exhibit up to 110-fold fluorescence enhancement in biomembranes and enable cellular imaging at 1 nM concentration, which make them the brightest membrane probes to date.

Original languageEnglish
Pages (from-to)17136-17139
Number of pages4
JournalChemical Communications
Volume51
Issue number96
DOIs
StatePublished - 2015
Externally publishedYes

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