TY - JOUR
T1 - Breast cancer in the elderly
T2 - Histological, hormonal and surgical characteristics
AU - Pappo, I.
AU - Karni, T.
AU - Sandbank, J.
AU - Dinur, I.
AU - Sella, A.
AU - Stahl-Kent, V.
AU - Wasserman, I.
AU - Halevy, A.
PY - 2007/2
Y1 - 2007/2
N2 - The characteristics, menstrual risk factors and surgical therapy of 187 consecutive patients more than 70 years of age (mean: 75.9) were investigated and compared with those of 609 patients less than 70 years of age (mean: 53.9). There was no difference in stage, size, state of axillary nodes, grade, histological types, Ki-67, vascular invasion, estrogen receptor rate, and HER-2/neu (+) rate. Positive progesterone receptor rate was higher in older patients (54.7% vs. 63.1%). Tumors were larger (p = 0.01) and their stage higher (p = 0.014) in patients more than 80 years of age. All menstrual risk factors were similar in the two groups. Positive familial history was more frequent in patients <60 years. Significantly more young patients used hormone replacement therapy (HRT) (21.8 vs. 8.6%). Older patients underwent less breast-conserving surgery (36.1 vs. 55.1%), and less axillary lymph node dissection (ALND) (69.7 vs. 84.9%). We conclude that breast cancer characteristics and menstrual risk factors are similar in the two age groups.
AB - The characteristics, menstrual risk factors and surgical therapy of 187 consecutive patients more than 70 years of age (mean: 75.9) were investigated and compared with those of 609 patients less than 70 years of age (mean: 53.9). There was no difference in stage, size, state of axillary nodes, grade, histological types, Ki-67, vascular invasion, estrogen receptor rate, and HER-2/neu (+) rate. Positive progesterone receptor rate was higher in older patients (54.7% vs. 63.1%). Tumors were larger (p = 0.01) and their stage higher (p = 0.014) in patients more than 80 years of age. All menstrual risk factors were similar in the two groups. Positive familial history was more frequent in patients <60 years. Significantly more young patients used hormone replacement therapy (HRT) (21.8 vs. 8.6%). Older patients underwent less breast-conserving surgery (36.1 vs. 55.1%), and less axillary lymph node dissection (ALND) (69.7 vs. 84.9%). We conclude that breast cancer characteristics and menstrual risk factors are similar in the two age groups.
KW - Breast cancer
KW - Elderly patients
KW - Hormonal risk factors
KW - Mastectomy
UR - http://www.scopus.com/inward/record.url?scp=33846681318&partnerID=8YFLogxK
U2 - 10.1016/j.breast.2006.05.007
DO - 10.1016/j.breast.2006.05.007
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 17276293
AN - SCOPUS:33846681318
SN - 0960-9776
VL - 16
SP - 60
EP - 67
JO - Breast
JF - Breast
IS - 1
ER -