Body mass index and socioeconomic status measured in adolescence, country of origin, and the incidence of gastroesophageal adenocarcinoma in a cohort of 1 million men

Zohar Levi, Jeremy D. Kark, Ari Shamiss, Estela Derazne, Dorit Tzur, Lital Keinan-Boker, Irena Liphshitz, Yaron Niv, Moshe Furman, Arnon Afek

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

BACKGROUND To the authors' knowledge, little work has been done concerning adolescent precursors for gastroesophageal cancer. In the current study, the association of adolescent overweight as well as socioeconomic status (SES) with the incidence of esophageal adenocarcinoma (EAC), gastroesophageal junction adenocarcinoma (GEJAC), and noncardia gastric cancer (NCGC) was evaluated. METHODS Body mass index (BMI) was measured in 1 million Israeli adolescent males who underwent a general health examination at a mean age of 17.3 ± 0.5 years from 1967 to 2005. Overweight was defined as a BMI ≥ 85th percentile of the standard US distribution in adolescence. Incident cancer was identified by linkage with the Israeli National Cancer Registry. RESULTS A total of 182 incident cancer cases were documented (52 combined EAC and GEJAC cases and 130 NCGC cases). Adolescent overweight at baseline (BMI ≥ 85th percentile) was associated with an increased risk in the combined group of cases of EAC and GEJAC (multivariable hazards ratio [HR], 2.1; 95% confidence interval [95% CI], 1.1-4.3 [P =.032]). Low SES (the lowest category vs the highest) as well as low number of years of education (≤ 9 years) were associated with an increased risk of intestinal-type NCGC (multivariable HR, 2.2; 95% CI, 1.0-4.8 [P =.041] and multivariable HR, 1.9; 95% CI, 1.1-3.19 [P =.020], respectively). The adjusted risk of NCGC was higher in immigrants born in Asian countries and the former Soviet Union. CONCLUSIONS Overweight during adolescence was found to be substantially associated with the subsequent development of EAC and GEJAC. In addition, although potential confounding by Helicobacter pylori infection status or lifestyle factors was not fully accounted for in the analyses, lower SES as well as immigration from higher-risk countries are important determinants of NCGC.

Original languageEnglish
Pages (from-to)4086-4093
Number of pages8
JournalCancer
Volume119
Issue number23
DOIs
StatePublished - 1 Dec 2013
Externally publishedYes

Keywords

  • adolescence
  • gastroesophageal cancer
  • obesity
  • socioeconomic status

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