TY - JOUR
T1 - Biomarkers of maternal diabetes and its complication in pregnancy
AU - Ornoy, Asher
PY - 2012/9
Y1 - 2012/9
N2 - There are specific biomarkers - indicators of normal and abnormal processes - in diabetic pregnancies that predict the degree of diabetic control as well as embryonic and fetal growth and development. They can be detected in maternal blood, amniotic fluid or in the cord plasma of the newborn infant. While the cord plasma levels are of little clinical relevance because they do not allow us to interfere with the outcome of pregnancy, biomarkers in maternal blood or amniotic fluid may help us to better control the outcome of diabetic pregnancies. Important biomarkers in maternal blood are fasting glucose, HbA1c and IGFs. Relevant biomarkers in amniotic fluid are insulin, erythropoietin and markers of bone formation and resorption. Cord plasma biomarkers include IGFs, leptin, adiponectin, resistin, markers of oxidative stress and of hypoxia. Whether these biomarkers can be predictors of long term outcome in infants of diabetic mothers is yet to be determined.
AB - There are specific biomarkers - indicators of normal and abnormal processes - in diabetic pregnancies that predict the degree of diabetic control as well as embryonic and fetal growth and development. They can be detected in maternal blood, amniotic fluid or in the cord plasma of the newborn infant. While the cord plasma levels are of little clinical relevance because they do not allow us to interfere with the outcome of pregnancy, biomarkers in maternal blood or amniotic fluid may help us to better control the outcome of diabetic pregnancies. Important biomarkers in maternal blood are fasting glucose, HbA1c and IGFs. Relevant biomarkers in amniotic fluid are insulin, erythropoietin and markers of bone formation and resorption. Cord plasma biomarkers include IGFs, leptin, adiponectin, resistin, markers of oxidative stress and of hypoxia. Whether these biomarkers can be predictors of long term outcome in infants of diabetic mothers is yet to be determined.
KW - Anomalies
KW - Biomarkers
KW - Fetus
KW - Maternal diabetes
KW - Pregnancy outcome
UR - http://www.scopus.com/inward/record.url?scp=84864008140&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2012.05.005
DO - 10.1016/j.reprotox.2012.05.005
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C2 - 22659274
AN - SCOPUS:84864008140
SN - 0890-6238
VL - 34
SP - 174
EP - 179
JO - Reproductive Toxicology
JF - Reproductive Toxicology
IS - 2
ER -