Abstract
We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-α) was proconvulsive in this respect. The present study shows that TNF-α, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-α may play a protective role in neurologic complications of S. dysenteriae infection.
| Original language | English |
|---|---|
| Pages (from-to) | 2288-2291 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 71 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Apr 2003 |
| Externally published | Yes |