TY - JOUR
T1 - Bidirectional concentration-dependent effects of tumor necrosis factor alpha in Shigella dysenteriae-related seizures
AU - Yuhas, Yael
AU - Weizman, Abraham
AU - Ashkenazi, Shai
PY - 2003/4/1
Y1 - 2003/4/1
N2 - We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-α) was proconvulsive in this respect. The present study shows that TNF-α, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-α may play a protective role in neurologic complications of S. dysenteriae infection.
AB - We have previously demonstrated that pretreatment of mice with Shigella dysenteriae sonicate enhanced their susceptibility to pentylenetetrazole-induced seizures and that tumor necrosis factor alpha (TNF-α) was proconvulsive in this respect. The present study shows that TNF-α, at high concentrations, may also exert a suppressive effect on Shigella-mediated seizures. This implies that high levels of TNF-α may play a protective role in neurologic complications of S. dysenteriae infection.
UR - http://www.scopus.com/inward/record.url?scp=0037379562&partnerID=8YFLogxK
U2 - 10.1128/IAI.71.4.2288-2291.2003
DO - 10.1128/IAI.71.4.2288-2291.2003
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C2 - 12654859
AN - SCOPUS:0037379562
SN - 0019-9567
VL - 71
SP - 2288
EP - 2291
JO - Infection and Immunity
JF - Infection and Immunity
IS - 4
ER -