BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice

Britta Hardy; Sara Morgenstern; Annat Raiter; Galina Rodionov; Ludmilla Fadaeev; Yaron Niv

doi:10.1016/j.canlet.2005.06.046

BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice

Britta Hardy, Sara Morgenstern, Annat Raiter, Galina Rodionov, Ludmilla Fadaeev, Yaron Niv

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.

Original language	English
Pages (from-to)	217-222
Number of pages	6
Journal	Cancer Letters
Volume	229
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2005.06.046
State	Published - 18 Nov 2005
Externally published	Yes

Keywords

BAT monoclonal antibody
Cancer immunotherapy
Liver histopathology
Liver metastases
Metastatic colorectal carcinoma
Mice tumor model

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10.1016/j.canlet.2005.06.046

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title = "BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice",

abstract = "BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.",

keywords = "BAT monoclonal antibody, Cancer immunotherapy, Liver histopathology, Liver metastases, Metastatic colorectal carcinoma, Mice tumor model",

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AU - Hardy, Britta

AU - Morgenstern, Sara

AU - Raiter, Annat

AU - Rodionov, Galina

AU - Fadaeev, Ludmilla

AU - Niv, Yaron

PY - 2005/11/18

Y1 - 2005/11/18

N2 - BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.

AB - BAT monoclonal antibody exhibited anti-tumor activity mediated by T and NK cells. We have evaluated the efficacy of murine and humanized BAT for the treatment of human colorectal carcinoma liver metastases in nude mice. HM7, a human colorectal carcinoma was injected into the spleen to colonize the liver. A single intravenous administration of both BAT antibodies significantly reduced the number of metastases and liver weights. Histological examinations demonstrated lymphocyte accumulation near remnant tumors and in tumor-free tissues of BAT treated mice. The efficacy of humanized BAT in the regression of hepatic metastases in human colorectal carcinoma has potential clinical use.

KW - BAT monoclonal antibody

KW - Cancer immunotherapy

KW - Liver histopathology

KW - Liver metastases

KW - Metastatic colorectal carcinoma

KW - Mice tumor model

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BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice

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Keywords

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